Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.16/1648
Título: Identification of novel nucleus pulposus markers: Interspecies variations and implications for cell-based therapiesfor intervertebral disc degeneration
Autor: Rodrigues-Pinto, R.
Richardson, S.
Hoyland, J.
Palavras-chave: Animal models
Cell-based therapies
Disc degeneration
Intervertebral disc
Mesenchymal stem cells
Nucleus pulposus
Phenotype
Data: 2013
Editora: British Editorial Society of Bone and Joint Surgery
Citação: Bone Joint Res 2013;2:169–78.
Resumo: Mesenchymal stem-cell based therapies have been proposed as novel treatments for intervertebral disc degeneration, a prevalent and disabling condition associated with back pain. The development of these treatment strategies, however, has been hindered by the incomplete understanding of the human nucleus pulposus phenotype and by an inaccurate interpretation and translation of animal to human research. This review summarises recent work characterising the nucleus pulposus phenotype in different animal models and in humans and integrates their findings with the anatomical and physiological differences between these species. Understanding this phenotype is paramount to guarantee that implanted cells restore the native functions of the intervertebral disc.
Peer review: yes
URI: http://hdl.handle.net/10400.16/1648
DOI: 10.1302/2046-3758.28.2000184.
Versão do Editor: http://www.bjr.boneandjoint.org.uk/content/2/8/169.full.pdf+html
Aparece nas colecções:SOME - Artigos publicados em revistas indexadas na Medline
SO - Artigos publicados em revistas indexadas na Medline

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