Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.16/1685
Título: Tumor regression grades: can they influence rectal cancer therapy decision tree?
Autor: Santos, M.
Silva, C.
Rocha, A.
Matos, E.
Nogueira, C.
Lopes, C.
Data: 2013
Editora: Hindawi Publishing Corporation
Citação: Marisa D. Santos, Cristina Silva, Anabela Rocha, Eduarda Matos, Carlos Nogueira, and Carlos Lopes, “Tumor Regression Grades: Can They Influence Rectal Cancer Therapy Decision Tree?,” International Journal of Surgical Oncology, vol. 2013, Article ID 572149, 8 pages, 2013. doi:10.1155/2013/572149
Resumo: BACKGROUND: Evaluating impact of tumor regression grade in prognosis of patients with locally advanced rectal cancer (LARC). MATERIALS AND METHODS: We identified from our colorectal cancer database 168 patients with LARC who received neoadjuvant therapy followed by complete mesorectum excision surgery between 2003 and 2011: 157 received 5-FU-based chemoradiation (CRT) and 11 short course RT. We excluded 29 patients, the remaining 139 were reassessed for disease recurrence and survival; the slides of surgical specimens were reviewed and classified according to Mandard tumor regression grades (TRG). We compared patients with good response (Mandard TRG1 or TRG2) versus patients with bad response (Mandard TRG3, TRG4, or TRG5). Outcomes evaluated were 5-year overall survival (OS), disease-free survival (DFS), local, distant and mixed recurrence. RESULTS: Mean age was 64.2 years, and median followup was 56 months. No statistically significant survival difference was found when comparing patients with Mandard TRG1 versus Mandard TRG2 (p = .77). Mandard good responders (TRG1 + 2) have significantly better OS and DFS than Mandard bad responders (TRG3 + 4 + 5) (OS p = .013; DFS p = .007). CONCLUSIONS: Mandard good responders had a favorable prognosis. Tumor response (TRG) to neoadjuvant chemoradiation should be taken into account when defining the optimal adjuvant chemotherapy regimen for patients with LARC
Peer review: yes
URI: http://hdl.handle.net/10400.16/1685
DOI: 10.1155/2013/572149
ISSN: 2090-1402
Versão do Editor: http://www.hindawi.com/journals/ijso/2013/572149/
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