Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.16/1696
Título: Non-Transferrin-Bound Iron (NTBI) Uptake by T Lymphocytes: Evidence for the Selective Acquisition of Oligomeric Ferric Citrate Species
Autor: Arezes, J.
Costa, M.
Vieira, I.
Dias, V.
Kong, X.
Fernandes, R.
Vos, M.
Carlsson, A.
Rikers, Y.
Porto, G.
Rangel, M.
Hider, R.
Pinto, J.
Data: 2013
Editora: Public Library of Science
Citação: Arezes J, Costa M, Vieira I, Dias V, Kong XL, et al. (2013) Non-Transferrin-Bound Iron (NTBI) Uptake by T Lymphocytes: Evidence for the Selective Acquisition of Oligomeric Ferric Citrate Species. PLoS ONE 8(11): e79870. doi:10.1371/journal.pone.0079870
Resumo: Iron is an essential nutrient in several biological processes such as oxygen transport, DNA replication and erythropoiesis. Plasma iron normally circulates bound to transferrin. In iron overload disorders, however, iron concentrations exceed transferrin binding capacity and iron appears complexed with low molecular weight molecules, known as non-transferrin-bound iron (NTBI). NTBI is responsible for the toxicity associated with iron-overload pathologies but the mechanisms leading to NTBI uptake are not fully understood. Here we show for the first time that T lymphocytes are able to take up and accumulate NTBI in a manner that resembles that of hepatocytes. Moreover, we show that both hepatocytes and T lymphocytes take up the oligomeric Fe3Cit3 preferentially to other iron-citrate species, suggesting the existence of a selective NTBI carrier. These results provide a tool for the identification of the still elusive ferric-citrate cellular carrier and may also open a new pathway towards the design of more efficient iron chelators for the treatment of iron overload disorders.
Peer review: yes
URI: http://hdl.handle.net/10400.16/1696
DOI: 10.1371/journal.pone.0079870
ISSN: 1932-6203
Versão do Editor: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0079870
Aparece nas colecções:DH - Artigos publicados em revistas indexadas na Medline
SE - Artigos publicados em revistas indexadas na Medline
SHC - Artigos publicados em revistas indexadas na Medline

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