Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.16/1709
Título: HIV and HPV infections and ocular surface squamous neoplasia: systematic review and meta-analysis
Autor: Carreira, H.
Coutinho, F.
Carrilho, C.
Lunet, N.
Data: 2013
Editora: Lewis
Citação: Br J Cancer. 2013 Oct 1;109(7):1981-8. doi: 10.1038/bjc.2013.539.
Resumo: BACKGROUND: The frequency of ocular surface squamous neoplasias (OSSNs) has been increasing in populations with a high prevalence of infection with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) and infection with human papillomavirus (HPV). We aimed to quantify the association between HIV/AIDS and HPV infection and OSSN, through systematic review and meta-analysis. METHODS: The articles providing data on the association between HIV/AIDS and/or HPV infection and OSSN were identified in MEDLINE, SCOPUS and EMBASE searched up to May 2013, and through backward citation tracking. The DerSimonian and Laird method was used to compute summary relative risk (RR) estimates and 95% confidence intervals (95% CI). Heterogeneity was quantified with the I(2) statistic. RESULTS: HIV/AIDS was strongly associated with an increased risk of OSSN (summary RR=8.06, 95% CI: 5.29-12.30, I(2)=56.0%, 12 studies). The summary RR estimate for the infection with mucosal HPV subtypes was 3.13 (95% CI: 1.72-5.71, I(2)=45.6%, 16 studies). Four studies addressed the association between both cutaneous and mucosal HPV subtypes and OSSN; the summary RR estimates were 3.52 (95% CI: 1.23-10.08, I(2)=21.8%) and 1.08 (95% CI: 0.57-2.05, I(2)=0.0%), respectively. CONCLUSION: Human immunodeficiency virus infection increases the risk of OSSN by nearly eight-fold. Regarding HPV infection, only the cutaneous subtypes seem to be a risk factor.
Peer review: yes
URI: http://hdl.handle.net/10400.16/1709
DOI: 10.1038/bjc.2013.539
ISSN: 0007-0920
Versão do Editor: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790185/
Aparece nas colecções:DN - Artigos publicados em revistas indexadas na Medline
SOnc - Artigos publicados em revistas indexadas na Medline

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