Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.16/1867
Título: First trimester aneuploidy screening program for preeclampsia prediction in a portuguese obstetric population
Autor: Teixeira, C.
Tejera, E.
Martins, H.
Pereira, A.
Costa-Pereira, A
Rebelo, I
Data: 2014
Editora: Hindawi Publishing Corporation
Citação: Obstet Gynecol Int. 2014;2014:435037
Resumo: Objective. To evaluate the performance of a first trimester aneuploidy screening program for preeclampsia (PE) prediction in a Portuguese obstetric population, when performed under routine clinical conditions. Materials and Methods. Retrospective cohort study of 5672 pregnant women who underwent routine first trimester aneuploidy screening in a Portuguese university hospital from January 2009 to June 2013. Logistic regression-based predictive models were developed for prediction of PE based on maternal characteristics, crown-rump length (CRL), nuchal translucency thickness (NT), and maternal serum levels of pregnancy-associated plasma protein-A (PAPP-A) and free beta-subunit of human chorionic gonadotropin (free β -hCG). Results. At a false-positive rate of 5/10%, the detection rate for early-onset (EO-PE) and late-onset (LO-PE) PE was 31.4/45.7% and 29.5/35.2%, respectively. Although both forms of PE were associated with decreased PAPP-A, logistic regression analysis revealed significant contributions from maternal factors, free β -hCG, CRL, and NT, but not PAPP-A, for prediction of PE. Conclusion. Our findings support that both clinical forms of EO-PE and LO-PE can be predicted using a combination of maternal history and biomarkers assessed at first trimester aneuploidy screening. However, detection rates were modest, suggesting that models need to be improved with additional markers not included in the current aneuploidy screening programs.
Peer review: yes
URI: http://hdl.handle.net/10400.16/1867
DOI: 10.1155/2014/435037
ISSN: 1687-9589
Versão do Editor: http://dx.doi.org/10.1155/2014/435037
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