Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.16/1872
Título: HIV-2 integrase polymorphisms and longitudinal genotypic analysis of HIV-2 infected patients failing a raltegravir-containing regimen
Autor: Cavaco-Silva, J.
Abecasis, A.
Miranda, A.
Poças, J.
Narciso, J.
Águas, M.
Maltez, F.
Almeida, I.
Germano, I.
Diniz, A.
Gonçalves, M.
Gomes, P.
Cunha, C.
Camacho, R.
Data: 2014
Editora: Public Library of Science
Citação: PLoS One. 2014;9(3):e92747
Resumo: To characterize the HIV-2 integrase gene polymorphisms and the pathways to resistance of HIV-2 patients failing a raltegravir-containing regimen, we studied 63 integrase strand transfer inhibitors (INSTI)-naïve patients, and 10 heavily pretreated patients exhibiting virological failure while receiving a salvage raltegravir-containing regimen. All patients were infected by HIV-2 group A. 61.4% of the integrase residues were conserved, including the catalytic motif residues. No INSTI-major resistance mutations were detected in the virus population from naïve patients, but two amino acids that are secondary resistance mutations to INSTIs in HIV-1 were observed. The 10 raltegravir-experienced patients exhibited resistance mutations via three main genetic pathways: N155H, Q148R, and eventually E92Q - T97A. The 155 pathway was preferentially used (7/10 patients). Other mutations associated to raltegravir resistance in HIV-1 were also observed in our HIV-2 population (V151I and D232N), along with several novel mutations previously unreported. Data retrieved from this study should help build a more robust HIV-2-specific algorithm for the genotypic interpretation of raltegravir resistance, and contribute to improve the clinical monitoring of HIV-2-infected patients.
Peer review: yes
URI: http://hdl.handle.net/10400.16/1872
DOI: 10.1371/journal.pone.0092747
ISSN: 1932-6203
Versão do Editor: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0092747
Aparece nas colecções:UIC - Artigos publicados em revistas indexadas na Medline

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