Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.16/1878
Título: Effects of acute bleeding followed by hydroxyethyl starch 130/0.4 or a crystalloid on propofol concentrations, cerebral oxygenation, and electroencephalographic and haemodynamic variables in pigs
Autor: Silva, A.
Ortiz, A.
Venâncio, C.
Souza, A.
Ferreira, L.
Branco, P.
de Pinho, P.
Amorim, P.
Ferreira, D.
Data: 2014
Editora: Hindawi Publishing Corporation
Citação: Vet Med Int. 2014;2014:710394
Resumo: Bleeding changes the haemodynamics, compromising organ perfusion. In this study, the effects of bleeding followed by replacement with hydroxyethyl starch 130/0.4 (HES) or lactated Ringer's (LR) on cerebral oxygenation and electroencephalogram-derived parameters were investigated. Twelve young pigs under propofol-remifentanil anaesthesia were bled 30 mL/kg and, after a 20-minute waiting period, volume replacement was performed with HES (GHES; N = 6) or LR (GRL; N = 6). Bleeding caused a decrease of more than 50% in mean arterial pressure (P < 0.01) and a decrease in cerebral oximetry (P = 0.039), bispectral index, and electroencephalogram total power (P = 0.04 and P < 0.01, resp.), while propofol plasma concentrations increased (P < 0.01). Both solutions restored the haemodynamics and cerebral oxygenation similarly and were accompanied by an increase in electroencephalogram total power. No differences between groups were found. However, one hour after the end of the volume replacement, the cardiac output (P = 0.03) and the cerebral oxygenation (P = 0.008) decreased in the GLR and were significantly lower than in GHES (P = 0.02). Volume replacement with HES 130/0.4 was capable of maintaining the cardiac output and cerebral oxygenation during a longer period than LR and caused a decrease in the propofol plasma concentrations.
Peer review: yes
URI: http://hdl.handle.net/10400.16/1878
DOI: 10.1155/2014/710394
ISBN: 2090-8113
Versão do Editor: http://www.hindawi.com/journals/vmi/2014/710394/
Aparece nas colecções:SA - Artigos publicados em revistas indexadas na Medline

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