Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.16/1879
Título: Autoimmune diabetes recurrence should be routinely monitored after pancreas transplantation
Autor: Martins, L.
Palavras-chave: Autoantibodies
Autoimmune type 1 diabetes
Pancreas transplantation
Type 1 diabetes recurrence
Data: 24-Set-2014
Editora: Baishideng Publishing Group
Citação: World J Transplant 2014 September 24; 4(3): 183-187
Resumo: Autoimmune type 1 diabetes recurrence in pancreas grafts was first described 30 years ago, but it is not yet completely understood. In fact, the number of transplants affected and possibly lost due to this disease may be falsely low. There may be insufficient awareness to this entity by clinicians, leading to underdiagnosis. Some authors estimate that half of the immunological losses in pancreas transplantation are due to autoimmunity. Pancreas biopsy is the gold standard for the definitive diagnosis. However, as an invasive procedure, it is not the ideal approach to screen the disease. Pancreatic autoantibodies which may be detected early before graft dysfunction, when searched for, are probably the best initial tool to establish the diagnosis. The purpose of this review is to revisit the autoimmune aspects of type 1 diabetes and to analyse data about the identified autoantibodies, as serological markers of the disease. Therapeutic strategies used to control the disease, though with unsatisfactory results, are also addressed. In addition, the author's own experience with the prospective monitoring of pancreatic autoantibodies after transplantation and its correlation with graft outcome will be discussed.
Peer review: yes
URI: http://hdl.handle.net/10400.16/1879
DOI: 10.5500/wjt.v4.i3.183
ISSN: 2220-3230
Versão do Editor: http://www.wjgnet.com/2220-3230/full/v4/i3/183.htm
Aparece nas colecções:SNEF - Artigos publicados em revistas indexadas na Medline

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