Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.16/2160
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degois.publication.firstPage483pt_PT
degois.publication.issue5pt_PT
degois.publication.lastPage491pt_PT
degois.publication.locationChinapt_PT
degois.publication.titleTranslational lung cancer researchpt_PT
dc.relation.publisherversionhttp://tlcr.amegroups.com/article/view/10203/8656pt_PT
dc.contributor.authorReclusa, P.-
dc.contributor.authorSirera, R.-
dc.contributor.authorAraujo, A.-
dc.contributor.authorGiallombardo, M.-
dc.contributor.authorValentino, A.-
dc.contributor.authorSorber, L.-
dc.contributor.authorBazo, I.-
dc.contributor.authorPauwels, P.-
dc.contributor.authorRolfo, C.-
dc.date.accessioned2017-07-24T15:01:22Z-
dc.date.available2017-07-24T15:01:22Z-
dc.date.issued2016-10-
dc.identifier.citationTransl Lung Cancer Res. 2016 Oct;5(5):483-491pt_PT
dc.identifier.issn2226-4477-
dc.identifier.issn2218-6751-
dc.identifier.urihttp://hdl.handle.net/10400.16/2160-
dc.description.abstractLung cancer is a highly lethal disease. Targeted therapies have been developed in last years, however survival rates are not improving due to the delay in the diagnosis, making biomarkers one of the most interesting fields of study in cancer. Liquid biopsy has raised as an alternative to tissue biopsy due to improvements in analytical techniques for circulating tumor cells (CTCs), cell free DNA and exosomes. Among all, exosomes have raised as one of the most promising tools to understand the tumor due to their stability in the blood and their similarity to the cells of origin. In the last years, different alterations have been described inside the exosomes derived from non-small cell lung cancer (NSCLC) cells mirroring the processes inside these tumoral cells, such as EGFR mutation, translocations or microRNA (miRNA) deregulation. All these studies have opened the window to a new world of possibilities in the study of tumor biomarkers.pt_PT
dc.language.isoengpt_PT
dc.publisherPioneer Bioscience Publishing Companypt_PT
dc.rightsopenAccesspt_PT
dc.subjectNon-small cell lung cancer (NSCLC)pt_PT
dc.subjectexosomespt_PT
dc.subjectliquid biopsypt_PT
dc.subjectncRNAspt_PT
dc.titleExosomes genetic cargo in lung cancer: a truly Pandora's boxpt_PT
dc.typearticlept_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.peerreviewedyespt_PT
degois.publication.volume5pt_PT
dc.identifier.doi10.21037/tlcr.2016.10.06pt_PT
Aparece nas colecções:SOnc - Artigos publicados em revistas indexadas na Medline

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