Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.16/2161
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degois.publication.locationUnited States of Americapt_PT
degois.publication.titleWorld Journal of Transplantationpt_PT
dc.contributor.authorSantos, S.-
dc.contributor.authorMalheiro, J.-
dc.contributor.authorTafulo, S.-
dc.contributor.authorDias, L.-
dc.contributor.authorCarmo, R.-
dc.contributor.authorSampaio, S.-
dc.contributor.authorCosta, M.-
dc.contributor.authorCampos, A.-
dc.contributor.authorPedroso, S.-
dc.contributor.authorAlmeida, M.-
dc.contributor.authorMartins, L.-
dc.contributor.authorHenriques, C.-
dc.contributor.authorCabrita, A.-
dc.identifier.citationWorld J Transplant. 2016 Dec 24;6(4):689-696pt_PT
dc.description.abstractAIM: To analyze the clinical impact of preformed antiHLA-Cw vs antiHLA-A and/or -B donor-specific antibodies (DSA) in kidney transplantation. METHODS: Retrospective study, comparing 12 patients transplanted with DSA exclusively antiHLA-Cw with 23 patients with preformed DSA antiHLA-A and/or B. RESULTS: One year after transplantation there were no differences in terms of acute rejection between the two groups (3 and 6 cases, respectively in the DSA-Cw and the DSA-A-B groups; P = 1). At one year, eGFR was not significantly different between groups (median 59 mL/min in DSA-Cw group, compared to median 51 mL/min in DSA-A-B group, P = 0.192). Moreover, kidney graft survival was similar between groups at 5-years (100% in DSA-Cw group vs 91% in DSA-A-B group, P = 0.528). The sole independent predictor of antibody mediated rejection (AMR) incidence was DSA strength (HR = 1.07 per 1000 increase in MFI, P = 0.034). AMR was associated with shortened graft survival at 5-years, with 75% and 100% grafts surviving in patients with or without AMR, respectively (Log-rank P = 0.005). CONCLUSION: Our data indicate that DSA-Cw are associated with an identical risk of AMR and impact on graft function in comparison with "classical" class I DSA.pt_PT
dc.publisherBaishideng Publishing Grouppt_PT
dc.subjectAnti human leukocyte antigen class Ipt_PT
dc.subjectAntiHLA-Cw antibodiespt_PT
dc.subjectAntibody-mediated rejectionpt_PT
dc.subjectDonor-specific antibodiespt_PT
dc.subjectGraft survivalpt_PT
dc.subjectSolid-phase immunoassayspt_PT
dc.titleImpact of preformed donor-specific antibodies against HLA class I on kidney graft outcomes: Comparative analysis of exclusively anti-Cw vs anti-A and/or -B antibodiespt_PT
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