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Title: Efficacy and Safety of Direct-Acting Oral Anticoagulants Use in Acute Portal Vein Thrombosis Unrelated to Cirrhosis
Author: Nery, F.
Valadares, D.
Morais, S.
Teixeira-Gomes, M.
De Gottardi, A.
Keywords: Anticoagulation
Direct-acting oral anticoagulants
Portal vein thrombosis
Issue Date: Apr-2017
Publisher: Elmer Press
Citation: Gastroenterology Res. 2017 Apr;10(2):141-143
Abstract: In acute portal vein thrombosis (APVT) unrelated to cirrhosis, anticoagulant therapy is classically started with low molecular weight heparin or vitamin K antagonists. New direct-acting oral anticoagulants (DOACs) are used in the treatment of venous thrombosis outside the splanchnic vascular bed, but not in the latter. We report a young female with APVT occurring in a non-cirrhotic liver linked to heterozygosity of factor V-Leiden and prothrombin G20210A gene mutations. Rivaroxaban was started, with total recanalization of the left and partial recanalization of the right portal vein branches, without complications. New DOACs do not need daily subcutaneous injections nor routinely blood coagulation control tests, making its use attractive, eventually increasing patient's compliance. If proved to be safe and effective in the future studies, its use may be extended to PVT treatment. This case shows that rivaroxaban was safe, not only prevented the extension of thrombosis in the portal tract, but also resolved PVT, at least partially.
Peer review: yes
DOI: 10.14740/gr806w
ISSN: 1918-2805
Publisher Version:
Appears in Collections:SHC - Artigos publicados em revistas indexadas na Medline
SRD - Artigos publicados em revistas indexadas na Medline
SCI1- Artigos publicados em revistas indexadas na Medline

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