Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.16/2200
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degois.publication.firstPagee0169102pt_PT
degois.publication.issue1pt_PT
degois.publication.locationUnited States of Americapt_PT
degois.publication.titlePLoS ONEpt_PT
dc.relation.publisherversionhttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0169102pt_PT
dc.contributor.authorCosta-Pereira, C.-
dc.contributor.authorDurães, C.-
dc.contributor.authorCoelho, R.-
dc.contributor.authorGrácio, D.-
dc.contributor.authorSilva, M.-
dc.contributor.authorPeixoto, A.-
dc.contributor.authorLago, P.-
dc.contributor.authorPereira, M.-
dc.contributor.authorCatarino, T.-
dc.contributor.authorPinho, S.-
dc.contributor.authorTeixeira, J.-
dc.contributor.authorMacedo, G.-
dc.contributor.authorAnnese, V.-
dc.contributor.authorMagro, F.-
dc.date.accessioned2018-07-05T14:28:43Z-
dc.date.available2018-07-05T14:28:43Z-
dc.date.issued2017-
dc.identifier.citationCosta Pereira C, Durães C, Coelho R, Grácio D, Silva M, Peixoto A, et al. (2017) Association between Polymorphisms in Antioxidant Genes and Inflammatory Bowel Disease. PLoS ONE 12(1): e0169102. https://doi.org/10.1371/journal.pone.0169102pt_PT
dc.identifier.issn1932-6203-
dc.identifier.urihttp://hdl.handle.net/10400.16/2200-
dc.description.abstractInflammation is the driving force in inflammatory bowel disease (IBD) and its link to oxidative stress and carcinogenesis has long been accepted. The antioxidant system of the intestinal mucosa in IBD is compromised resulting in increased oxidative injury. This defective antioxidant system may be the result of genetic variants in antioxidant genes, which can represent susceptibility factors for IBD, namely Crohn's disease (CD) and ulcerative colitis (UC). Single nucleotide polymorphisms (SNPs) in the antioxidant genes SOD2 (rs4880) and GPX1 (rs1050450) were genotyped in a Portuguese population comprising 436 Crohn's disease and 367 ulcerative colitis patients, and 434 healthy controls. We found that the AA genotype in GPX1 is associated with ulcerative colitis (OR = 1.93, adjusted P-value = 0.037). Moreover, we found nominal significant associations between SOD2 and Crohn's disease susceptibility and disease subphenotypes but these did not withstand the correction for multiple testing. These findings indicate a possible link between disease phenotypes and antioxidant genes. These results suggest a potential role for antioxidant genes in IBD pathogenesis and should be considered in future association studies.pt_PT
dc.description.sponsorshipThis work was supported by a grant from the Portuguese Study Group for Inflammatory Bowel Disease (GEDII) [http://www.gedii.pt/_bolsas_e_premios_a_decorrer]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscriptpt_PT
dc.language.isoengpt_PT
dc.publisherPublic Library of Sciencept_PT
dc.rightsopenAccesspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleAssociation between Polymorphisms in Antioxidant Genes and Inflammatory Bowel Diseasept_PT
dc.typearticlept_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.peerreviewedyespt_PT
degois.publication.volume12pt_PT
dc.identifier.doi10.1371/journal.pone.0169102pt_PT
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