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Title: Predictive clinical model of tumor response after chemoradiation in rectal cancer
Author: Santos, M.
Silva, C.
Rocha, A.
Nogueira, C.
Castro-Poças, F.
Araujo, A.
Matos, E.
Pereira, C.
Medeiros, R.
Lopes, C.
Keywords: molecular marker
neoadjuvant chemoradiation
neutrophil lymphocyte ratio
rectal cancer
Issue Date: 28-Jul-2017
Publisher: Impact Journals
Citation: Oncotarget. 2017 Jul 28;8(35):58133-58151
Abstract: Survival improvement in rectal cancer treated with neoadjuvant chemoradiotherapy (nCRT) is achieved only if pathological response occurs. Mandard tumor regression grade (TRG) proved to be a valid system to measure nCRT response. The ability to predict tumor response before treatment may significantly have impact the selection of patients for nCRT in rectal cancer. The aim is to identify potential predictive pretreatment factors for Mandard response and build a clinical predictive model design. 167 patients with locally advanced rectal cancer were treated with nCRT and curative surgery. Blood cell counts in peripheral blood were analyzed. Pretreatment biopsies expression of cyclin D1, epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF) and protein 21 were assessed. A total of 61 single nucleotide polymorphisms were characterized using the Sequenom platform through multiplex amplification followed by mass-spectometric product separation. Surgical specimens were classified according to Mandard TRG. The patients were divided as: "good responders" (Mandard TRG1-2) and "poor responders" (Mandard TGR3-5). We examined predictive factors for Mandard response and performed statistical analysis. In univariate analysis, distance from anal verge, neutrophil lymphocyte ratio (NLR), cyclin D1, VEGF, EGFR, protein 21 and rs1810871 interleukin 10 (IL10) gene polymorphism are the pretreatment variables with predictive value for Mandard response. In multivariable analysis, NLR, cyclin D1, protein 21 and rs1800871 in IL10 gene maintain predictive value, allowing a clinical model design.
Peer review: yes
DOI: 10.18632/oncotarget.19651
ISSN: 1949-2553
Publisher Version:[]=19651&pubmed-linkout=1
Appears in Collections:SAP - Artigos publicados em revistas indexadas na Medline
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SG - Artigos publicados em revistas indexadas na Medline
Cir.1 - Artigos publicados em revistas indexadas na Medline

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