Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.16/2233
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degois.publication.firstPage58133pt_PT
degois.publication.issue35pt_PT
degois.publication.lastPage58151pt_PT
degois.publication.locationUnited States of Americapt_PT
degois.publication.titleOncotargetpt_PT
dc.relation.publisherversionhttp://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=19651&pubmed-linkout=1pt_PT
dc.contributor.authorSantos, M.-
dc.contributor.authorSilva, C.-
dc.contributor.authorRocha, A.-
dc.contributor.authorNogueira, C.-
dc.contributor.authorCastro-Poças, F.-
dc.contributor.authorAraujo, A.-
dc.contributor.authorMatos, E.-
dc.contributor.authorPereira, C.-
dc.contributor.authorMedeiros, R.-
dc.contributor.authorLopes, C.-
dc.date.accessioned2018-08-28T11:26:13Z-
dc.date.available2018-08-28T11:26:13Z-
dc.date.issued2017-07-28-
dc.identifier.citationOncotarget. 2017 Jul 28;8(35):58133-58151pt_PT
dc.identifier.issn1949-2553-
dc.identifier.urihttp://hdl.handle.net/10400.16/2233-
dc.description.abstractSurvival improvement in rectal cancer treated with neoadjuvant chemoradiotherapy (nCRT) is achieved only if pathological response occurs. Mandard tumor regression grade (TRG) proved to be a valid system to measure nCRT response. The ability to predict tumor response before treatment may significantly have impact the selection of patients for nCRT in rectal cancer. The aim is to identify potential predictive pretreatment factors for Mandard response and build a clinical predictive model design. 167 patients with locally advanced rectal cancer were treated with nCRT and curative surgery. Blood cell counts in peripheral blood were analyzed. Pretreatment biopsies expression of cyclin D1, epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF) and protein 21 were assessed. A total of 61 single nucleotide polymorphisms were characterized using the Sequenom platform through multiplex amplification followed by mass-spectometric product separation. Surgical specimens were classified according to Mandard TRG. The patients were divided as: "good responders" (Mandard TRG1-2) and "poor responders" (Mandard TGR3-5). We examined predictive factors for Mandard response and performed statistical analysis. In univariate analysis, distance from anal verge, neutrophil lymphocyte ratio (NLR), cyclin D1, VEGF, EGFR, protein 21 and rs1810871 interleukin 10 (IL10) gene polymorphism are the pretreatment variables with predictive value for Mandard response. In multivariable analysis, NLR, cyclin D1, protein 21 and rs1800871 in IL10 gene maintain predictive value, allowing a clinical model design.pt_PT
dc.description.sponsorshipThis study was supported by a research grant from the Associação de Apoio ao Departamento de Cirurgia do HSA and from DEFI/CHP. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.pt_PT
dc.language.isoengpt_PT
dc.publisherImpact Journalspt_PT
dc.rightsopenAccesspt_PT
dc.subjectmolecular markerpt_PT
dc.subjectneoadjuvant chemoradiationpt_PT
dc.subjectneutrophil lymphocyte ratiopt_PT
dc.subjectpredictionpt_PT
dc.subjectrectal cancerpt_PT
dc.titlePredictive clinical model of tumor response after chemoradiation in rectal cancerpt_PT
dc.typearticlept_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.peerreviewedyespt_PT
degois.publication.volume8pt_PT
dc.identifier.doi10.18632/oncotarget.19651pt_PT
Aparece nas colecções:SAP - Artigos publicados em revistas indexadas na Medline
SOnc - Artigos publicados em revistas indexadas na Medline
SG - Artigos publicados em revistas indexadas na Medline
Cir.1 - Artigos publicados em revistas indexadas na Medline

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