Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.16/355
Título: Thalamic Lesions in Vascular Dementia: Low Sensitivity of Fluid-Attenuated Inversion Recovery (FLAIR) Imaging
Autor: Bastos-Leite, A.
Straaten, E.
Scheltens, P.
Lycklama, G.
Barkhof, F.
Palavras-chave: dementia, vascular
magnetic resonance imaging
thalamus
Data: 2004
Editora: American Heart Association
Citação: Stroke. 2004;35:415-419.
Resumo: Background and Purpose—The criteria of the National Institute of Neurological Disorders and Stroke (NINDS)– Association Internationale pour la Recherche et l’Enseignement en Neurosciences (AIREN) include thalamic lesions for the diagnosis of vascular dementia (VaD). Although studies concerning VaD and brain aging advocate the use of fluid-attenuated inversion recovery (FLAIR) or T2-weighted images (T2-WI) to detect ischemic lesions, none compared the sensitivity of these sequences to depict thalamic lesions. Methods—We performed a blinded review of T2-WI and FLAIR images in 73 patients fulfilling the radiological part of the NINDS-AIREN criteria (mean age, 71 years; range, 49 to 83 years). This sample was drawn from a large multicenter trial on VaD and was expected to have a high prevalence of thalamic lesions. In a side-by-side review, including T1-weighted images as well, lesions were classified according to presumed underlying pathology. Results—The total number of thalamic lesions was 214. Two hundred eight (97%) were detected on T2-WI, but only 117 (55%) were detected on FLAIR ( 2 5.1; P 0.05). Although the mean size of lesions detected on T2-WI and not on FLAIR (4.4 mm) was significantly lower than the mean size of lesions detected on both sequences (6.7 mm) (P 0.001), 5 of the 29 lesions 10 mm on T2-WI were not visible on FLAIR. FLAIR detected only 81 (51%) of the 158 probable ischemic lesions and 30 (60%) of the 50 probable microbleeds. Conclusions—FLAIR should not be used as the only T2-weighted sequence to detect thalamic lesions in patients suspected of having VaD.
URI: http://hdl.handle.net/10400.16/355
ISSN: 1524-4628
Versão do Editor: http://stroke.ahajournals.org/cgi/content/full/35/2/415
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