Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.16/387
Outros títulos: Adipocytes and immune cells cross-talk: the role of catecholamines
Autor: Leite, F.
Data: 2-Jul-2010
Resumo: Background Obesity is reaching epidemic proportions worldwide, being characterised by long-term, low-grade inflammation with detrimental effects on virtually all physiological systems. Adipocyte dysfunction has been recently regarded as the instigator of the main metabolic disturbances observed in obesity and obesity-related comorbidities. Thus, the impact of this dysfunction upon major organic systems involved in obesity clearly needs to be determined. Given the intimate cross-talk between adipocytes and immune cells, and the recent discovery that immune cells are a source of cathecolamines (CA), we propose that these amines constitute an important link between neuroendocrine and immune networks. Consequently, we need to better understand the role of CA in modulation of the immune response in inflammatory-associated diseases such as obesity. Immune cell-derived CA alter a wide array of cell functions, including proliferation, differentiation, apoptosis and the pattern of cytokine expression, suggesting a crucial role in the inflammatory outcome. However, the exact mechanisms controlling the release of CA in obesity are not fully understood.
URI: http://hdl.handle.net/10400.16/387
Aparece nas colecções:SHC - Resumos de Comunicações Livres

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
Adipocytes and immune cells cross-talk - the role of catecholamines.pdf138,73 kBAdobe PDFVer/Abrir

FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote Degois 

Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.