Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.16/516
Título: Intraclonal diversity in a Sezary syndrome with a differential response to 2‐deoxycoformycin of the two lymphoma cell populations
Autor: GRANJO, E.
LIMA, M.
LOPES, J.M.
CUNHA, N.
TEIXEIRA, M. A.
SANTOS, F.
CANDEIAS, J.
RESENDE, C.
SANTOS, A.H.
BALANZATEGUI, A.
ORFAO, A.
MATUTES, E.
Data: Dez-2002
Editora: Wiley-Blackwell
Resumo: Br J Haematol. 2002 Dec;119(3):629-33. Intraclonal diversity in a Sezary syndrome with a differential response to 2-deoxycoformycin of the two lymphoma cell populations. Granjo E, Lima M, Lopes JM, Cunha N, Teixeira Mdos A, Santos F, Candeias J, Resende C, Santos AH, Balanzategui A, Orfão A, Matutes E. Department of Clinical Haematology, Hospital Geral de São João, Porto, Portugal. npp46740@mail.telpac.pt Abstract We report a case of Sezary syndrome with two abnormal CD4+ T-cell populations detected in the peripheral blood by flow cytometry immunophenotyping and DNA cell content, suggesting a biclonal T-cell lymphoproliferative disorder. Despite these findings, molecular analysis of the T-cell receptor genes was consistent with a monoclonal T-cell proliferation, supporting the existence of intraclonal diversity rather than a true biclonal disease. The patient achieved a transient response with 2-deoxycoformycin, with a selective decrease of the larger/hyperploid T-cell population; later on, an increased representation of this T-cell population was observed concomitantly with clinical relapse. PMID: 12437636 [PubMed - indexed for MEDLINE]
Peer review: yes
URI: http://hdl.handle.net/10400.16/516
ISSN: (ISSN: 0007-1048)
Versão do Editor: http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2141.2002.03889.x/pdf
Aparece nas colecções:SHC - Artigos publicados em revistas indexadas na Medline

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
pdf.7.pdf197,49 kBAdobe PDFVer/Abrir


FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote Degois 

Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.