Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.16/530
Título: Chronic eosinophilic leukaemia presenting with erythroderma, mild eosinophilia and hyper‐IgE: clinical, immunological and cytogenetic features and therapeutic approach. A case report.
Autor: GRANJO, E.
LIMA, M.
LOPES, J.M.
DORIA, S.
ORFAO, A.
YING, S.
BARATA, L.T.
MIRANDA, M.
CROSS, N.C.
BAIN, B.J.
Data: 2002
Editora: Karger
Resumo: Acta Haematol. 2002;107(2):108-12. Chronic eosinophilic leukaemia presenting with erythroderma, mild eosinophilia and hyper-IgE: clinical, immunological and cytogenetic features and therapeutic approach. A case report. Granjo E, Lima M, Lopes JM, Dória S, Orfão A, Ying S, Barata LT, Miranda M, Cross NC, Bain BJ. Department of Clinical Haematology, Hospital Geral de São João, Porto, Portugal. elisagranjo@netc.pt Abstract A 23-year-old, white male metallurgist presented with pruritic erythematous maculo-papules over the trunk and upper limbs and 6 months later developed erythroderma, eosinophilia and multi-organ dysfunction. A diagnosis of chronic eosinophilic leukaemia was made on the basis of myeloproliferative involvement of both peripheral blood and bone marrow, associated with eosinophilic differentiation and a t(5;12)(q33;p13) translocation. The initial therapeutic approach was interferon alfa-2b plus cytosine arabinoside, for 13 months, followed by hydroxyurea plus vincristine. There was improvement of skin lesions, disappearance of eosinophilia and decrease of serum immunoglobulin E, towards normal values. Copyright 2002 S. Karger AG, Basel PMID: 11919392 [PubMed - indexed for MEDLINE]
Peer review: yes
URI: http://hdl.handle.net/10400.16/530
ISSN: 0001-5792
Versão do Editor: http://content.karger.com/ProdukteDB/produkte.asp?Aktion=Ausgabe&Ausgabe=227422&ProduktNr=223829
Aparece nas colecções:SHC - Artigos publicados em revistas indexadas na Medline

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