Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.16/738
Título: Familial clustering of migraine: further evidence from a Portuguese study
Autor: Lemos, C.
Castro, M.
Barros, J.
Sequeiros, J.
Pereira-Monteiro, J.
Mendonça, D.
Sousa, A.
Data: Mar-2009
Editora: Wiley-Blackwell
Citação: Headache. 2009 Mar;49(3):404-11
Resumo: Abstract OBJECTIVE: Our aim was to evaluate familial aggregation of migraine in a large group of Portuguese families, and to assess if familial aggregation differs between MA and MO. METHODS: Familial aggregation was evaluated by estimating relative risk (RR) of migraine in 143 first-degree relatives of 50 probands with MA, in 196 first-degree relatives of 94 probands with MO and also in proband's spouses. Probands were enrolled in the study from a clinical sample and a population sample was used as reference. RESULTS: A significantly increased risk of migraine was found in both first-degree relatives of MO probands (RR = 3.7; 95% CI: 3.2-4.3) and of MA probands (RR = 3.6; 95% CI: 3.1-4.3), comparatively to the general population. Risk for spouses was not increased. First-degree relatives of MA probands and MO probands had a significantly increased risk of both MA and MO compared to the general population. In the group of MA probands, RR of MA in first-degree relatives reached a significant 4-fold increase when compared with RR of MO (RR(MA|MA) = 12.2, 95%CI: 7.7-19.5; RR(MO|MA) = 3.1, 95%CI: 2.5-3.8), while, in the group of MO probands, RR of MA was not significantly increased when compared with RR of MO (RR(MA|MO) = 5.3, 95%CI: 3.1-9.2; RR(MO|MO) = 4.0, 95%CI: 3.5-4.7). CONCLUSIONS: The present study focus on familial aggregation of migraine in a Portuguese population. Our results demonstrate a substantial familial risk of migraine with evidence of both common and specific etiologic mechanisms for either migraine subtypes.
Peer review: yes
URI: http://hdl.handle.net/10400.16/738
ISSN: 0017-8748
Aparece nas colecções:SN - Artigos publicados em revistas indexadas na Medline

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