Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.16/739
Título: BDNF and CGRP interaction: implications in migraine susceptibility
Autor: Lemos, C.
Mendonça, D.
Pereira-Monteiro, J.
Barros, J.
Sequeiros, J.
Alonso, I.
Sousa, A.
Data: Nov-2010
Editora: SAGE Publications
Citação: Cephalalgia. 2010 Nov;30(11):1375-82
Resumo: Abstract OBJECTIVES: Migraine pathophysiology involves several pathways. Our aims were to explore a possible role of the brain-derived neurotrophic factor gene (BDNF) in migraine susceptibility; to study, for the first time, the calcitonin gene-related peptide gene (CGRP); and a possible interaction between the two. METHODS: Using a case-control approach, four tagging single nucleotide polymorphisms (SNPs) (rs7124442, rs6265, rs11030107, and rs2049046) of BDNF and one tagging SNP-rs1553005-of CGRP were analyzed in 188 cases and 287 controls. A multivariable logistic regression was performed, adjusting for gender. Allelic and haplotypic frequencies were estimated. Interaction was assessed by a stepwise multivariable-logistic regression and confirmed by a multifactor dimensionality reduction analysis. RESULTS: No significant main effects were found; however, a significant interaction was found between BDNF and CGRP, showing an increased risk for the AT-genotype of rs2049046 and the GC-genotype of rs1553005 (odds ratio=1.88, 95% confidence interval: 1.20-2.93) for migraineurs. CONCLUSION: Our data support the hypothesis of an interaction between BDNF and CGRP in migraine susceptibility that should be further explored.
Peer review: yes
URI: http://hdl.handle.net/10400.16/739
ISSN: 0333-1024
Aparece nas colecções:SN - Artigos publicados em revistas indexadas na Medline

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