Browsing by Author "Couto, Maria Eduarda"
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- Aggressive Neuroblastoma in a Pediatric Patient with Severe Hemophilia APublication . Costa, Lídia; Couto, Maria Eduarda; Moutinho, Juliana; Ferreira, Ana Maia; Costa, Emilia; Roncon, Susana; Santos, Luisa Lopes; Cruz, Eugénia; Morais, SaraDespite the extensive information regarding hemophilia's hemorrhagic complications, the literature on cancer in hemophilia is scarce, especially in pediatric patients. Many uncertainties remain concerning diagnosis and workup. We report a rare case of two severe diseases (neuroblastoma and hemophilia A (HA)) concomitantly present in the same pediatric patient. We highlight that the diagnosis of severe HA did not have a negative impact on the patient's oncologic course. This case also illustrates the significance of the cooperation among different specialties and hospitals when caring for the same patient.
- Rhino-orbital-cerebral mucormycosis in a pediatric cancer patientPublication . Couto, Maria Eduarda; Oliva, Tereza; Alberto, Pedro; Lebre, Ana; Pinto, Armando; Ferreira, Ana MaiaAim: Mucormycosis infections are highly lethal in immunosuppressed patients. The authors present a rare case of successful treatment of the condition. Case description: A 14-year-old male with acute lymphoblastic lymphoma in remission was diagnosed with pansinusitis, cerebral osteomyelitis, and encephalitis with an abscess caused by Rhizopus sp. Neurosurgical drainage, endoscopic sinus surgery, and left eye enucleation were performed, and the patient was simultaneously treated with lipossomal-amphotericin B and posaconazol (later replaced by isavuconazol). However, complications (left frontal lobe herniation and cerebrospinal fluid fistula) ensued, requiring surgical reoperation. Chemotherapy was restarted four months later. Comments: This is a rare case report, in which early and aggressive surgery, antifungal treatment, and multidisciplinary team work were crucial for the successful outcome.