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Browsing by Author "Lima, Jorge"

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  • Association Between Preexisting Versus Newly Identified Atrial Fibrillation and Outcomes of Patients With Acute Pulmonary Embolism
    Publication . Bikdeli, Behnood; Jiménez, David; del Toro, Jorge; Piazza, Gregory; Rivas, Agustina; Fernández‐Reyes, José Luis; Sampériz, Ángel; Otero, Remedios; Suriñach, José María; Siniscalchi, Carmine; Martín‐Guerra, Javier Miguel; Castro, Joaquín; Muriel, Alfonso; Lip, Gregory Y. H.; Goldhaber, Samuel Z.; Monreal, Manuel; Monreal, Manuel; Prandoni, Paolo; Brenner, Benjamin; Farge‐Bancel, Dominique; Barba, Raquel; Di Micco, Pierpaolo; Bertoletti, Laurent; Schellong, Sebastian; Tzoran, Inna; Reis, Abilio; Bosevski, Marijan; Bounameaux, Henri; Malý, Radovan; Verhamme, Peter; Caprini, Joseph A.; Bui, Hanh My; Adarraga, María Dolores; Agud, María; Aibar, Jesús; Aibar, Miguel Ángel; Amado, Cristina; Arcelus, Juan Ignacio; Baeza, Carlos; Ballaz, Aitor; Barba, Raquel; Barbagelata, Cristina; Barrón, Manuel; Barrón‐Andrés, Belén; Blanco‐Molina, Ángeles; Botella, Ernesto; Camon, Ana María; Cañas, Inmaculada; Casado, Ignacio; Castro, Joaquín; Chasco, Leyre; Criado, Juan; de Ancos, Cristina; de Miguel, Javier; del Toro, Jorge; Demelo‐Rodríguez, Pablo; Díaz‐Peromingo, José Antonio; Di Campli, Mario Virgilio; Díez‐Sierra, Javier; Domínguez, Irene Milagros; Escribano, José Carlos; Falgá, Conxita; Farfán‐Sedano, Ana Isabel; Fernández‐Capitán, Carmen; Fernández‐Reyes, Jose Luis; Fidalgo, María Ángeles; Flores, Katia; Font, Carme; Font, Llorenç; Francisco, Iria; Gabara, Cristina; Galeano‐Valle, Francisco; Galindo, David; García, María Angelina; García‐Bragado, Ferrán; García de Herreros, Marta; García‐Hernáez, Raquel; García‐Mullor, María Mar; García‐Raso, Arantxa; Gavín‐Sebastián, Olga; Gil‐Díaz, Aida; Gómez‐Cuervo, Covadonga; Grau, Enric; Guirado, Leticia; Gutiérrez, Javier; Hernández‐Blasco, Luis; Hernando, Elena; Herreros, Miguel; Jara‐Palomares, Luis; Jaras, María Jesús; Jiménez, David; Jiménez, Rafael; Joya, Maria Dolores; León, José Manuel; Lima, Jorge; Llamas, Pilar; Lobo, José Luis; López‐Jiménez, Luciano; López‐Miguel, Patricia; López‐Núñez, Juan José; López‐Reyes, Raquel; López‐Ruiz, Antonio; López‐Sáez, Juan Bosco; Lorenzo, Alicia; Madridano, Olga; Maestre, Ana; Marchena, Pablo Javier; Martín del Pozo, Mar; Martín‐Guerra, Javier Miguel; Martín‐Martos, Francisco; Mella, Carmen; Mellado, Meritxell; Mercado, Maria Isabel; Moisés, Jorge; Monreal, Manuel; del Valle Morales, María; Muñoz‐Blanco, Arturo; Muñoz‐Rivas, Nuria; Navas, María Sierra; Nieto, Jose Antonio; Núñez‐Fernández, Manuel Jesús; Obispo, Berta; Olid, Mónica; Olivares, María Carmen; Orcastegui, José Luis; Ortega‐Michel, Clara; Osorio, Jeisson; Otalora, Sonia; Otero, Remedios; Parra, Pedro; Parra, Virginia; Pedrajas, José María; Pellejero, Galadriel; Porras, José Antonio; Portillo, José; Riera‐Mestre, Antoni; Rivas, Agustina; Rivera‐Civico, Francisco; Rodríguez‐Chiaradía, Diego Agustín; Rodríguez‐Cobo, Ana; Rodríguez‐Matute, Consolación; Rogado, Jacobo; Roig, Sonia; Rosa, Vladimir; Ruiz‐Artacho, Pedro; Ruiz‐Giménez, Nuria; Ruiz‐Ruiz, Justo; Ruiz‐Sada, Pablo; Salgueiro, Giorgina; Sánchez‐Martínez, Rosario; Sánchez‐Muñoz‐Torrero, Juan Francisco; Sancho, Teresa; Sirisi, Merçe; Soler, Silvia; Suriñach, José María; Tirado, Raimundo; Torres, María Isabel; Tolosa, Carles; Trujillo‐Santos, Javier; Uresandi, Fernando; Valero, Beatriz; Valle, Reina; Vela, Jerónimo Ramón; Vidal, Gemma; Villares, Paula; Zamora, Carles; Gutiérrez, Paula; Vázquez, Fernando Javier; Engelen, Matthias; Vanassche, Thomas; Verhamme, Peter; Hirmerova, Jana; Malý, Radovan; Salgado, Estuardo; Ait Abdallah, Nassim; Bertoletti, Laurent; Bura‐Riviere, Alessandra; Crichi, Benjamin; Debourdeau, Philippe; Olivier, Espitia; Falvo, Nicolas; Farge‐Bancel, Dominique; Galliazzo, Silvia; Helfer, Hélène; Mahé, Isabelle; Moustafa, Farès; Poenou, Geraldine; Schellong, Sebastian; Braester, Andrei; Brenner, Benjamin; Tzoran, Inna; Bilora, Franca; Bucherini, Eugenio; Ciammaichella, Maurizio; Di Micco, Pierpaolo; Imbalzano, Egidio; Maida, Rosa; Mastroiacovo, Daniela; Pace, Federica; Pesavento, Raffaele; Pomero, Fulvio; Prandoni, Paolo; Quintavalla, Roberto; Rocci, Anna; Romualdi, Roberta; Siniscalchi, Carmine; Tufano, Antonella; Visonà, Adriana; Zalunardo, Beniamino; Gibietis, Valdis; Kigitovica, Dana; Skride, Andris; Fonseca, Samuel; Martins, Filipa; Meireles, Jose; Bosevski, Marijan; Bounameaux, Henri; Mazzolai, Lucia; Bikdeli, Behnood; Caprini, Joseph A.; Tafur, Alfonso J.; Ochoa‐Chaar, Cassius Iyad; Weinberg, Ido; Wilkins, Hannah; Bui, Hanh My
    Background Atrial fibrillation (AF) may exist before or occur early in the course of pulmonary embolism (PE). We determined the PE outcomes based on the presence and timing of AF. Methods and Results Using the data from a multicenter PE registry, we identified 3 groups: (1) those with preexisting AF, (2) patients with new AF within 2 days from acute PE (incident AF), and (3) patients without AF. We assessed the 90-day and 1-year risk of mortality and stroke in patients with AF, compared with those without AF (reference group). Among 16 497 patients with PE, 792 had preexisting AF. These patients had increased odds of 90-day all-cause (odds ratio [OR], 2.81; 95% CI, 2.33-3.38) and PE-related mortality (OR, 2.38; 95% CI, 1.37-4.14) and increased 1-year hazard for ischemic stroke (hazard ratio, 5.48; 95% CI, 3.10-9.69) compared with those without AF. After multivariable adjustment, preexisting AF was associated with significantly increased odds of all-cause mortality (OR, 1.91; 95% CI, 1.57-2.32) but not PE-related mortality (OR, 1.50; 95% CI, 0.85-2.66). Among 16 497 patients with PE, 445 developed new incident AF within 2 days of acute PE. Incident AF was associated with increased odds of 90-day all-cause (OR, 2.28; 95% CI, 1.75-2.97) and PE-related (OR, 3.64; 95% CI, 2.01-6.59) mortality but not stroke. Findings were similar in multivariable analyses. Conclusions In patients with acute symptomatic PE, both preexisting AF and incident AF predict adverse clinical outcomes. The type of adverse outcomes may differ depending on the timing of AF onset.
    2021-09Journal article Open access Show more
  • Case Report: Pheochromocytoma and Synchronous Neuroblastoma in a Family With Hereditary Pheochromocytoma Associated With a MAX Deleterious Variant
    Publication . Duarte, Diana Borges; Ferreira, Lia; Santos, Ana P.; Costa, Cláudia; Lima, Jorge; Santos, Catarina; Afonso, Mariana; Teixeira, Manuel R.; Carvalho, Rui; Cardoso, Helena
    Introduction: Pheochromocytomas are rare catecholamine-producing neuroendocrine tumours arising from chromaffin cells of the adrenal medulla or extra-adrenal sympathetic paraganglia. Recent studies have indicated that up to 40% of pheochromocytomas could be attributable to an inherited germline variant in an increasing list of susceptibility genes. Germline variants of the MYC-associated factor (MAX) gene have been associated with familial pheochromocytomas and paragangliomas with an autosomal dominant pattern of inheritance, a median age at onset of 33 years and an overall frequency estimated at 1.9%. We describe a deleterious MAX variant associated with hereditary pheochromocytoma in a family with four affected individuals. Case presentation: The first patient presented with bilateral pheochromocytoma in 1995; genetic testing was proposed to his oldest son, when he was diagnosed with a bilateral pheochromocytoma with a synchronous neuroblastoma. Upon the identification of the MAX variant c.97C>T, p.(Arg33Ter), in the latter individual, his two siblings and their father were tested and the same variant was identified in all of them. Both siblings were subsequently diagnosed with pheochromocytoma (one of them bilateral) and choose to remain on active surveillance before they were submitted to adrenalectomy. All the tumours secreted predominantly norepinephrine, accordingly to the typical biochemical phenotype ascribed to variants in the MAX gene. Conclusion: This case series is, to our knowledge, the one with the largest number of individuals with hereditary pheochromocytoma with a deleterious MAX variant in the same family. It is also the first case with a synchronous pheochromocytoma and neuroblastoma in carriers of a MAX deleterious variant. This report draws attention to some ill-defined features of pheochromocytoma and other malignancies associated with a MAX variant and highlights the importance of understanding the genotype-phenotype correlation in hereditary pheochromocytoma and the impact of oriented genetic testing to detect, survey and treat patients and kindreds at risk.
    2021-03Journal article Open access Show more