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Browsing by Author "Saleiro, Rute"

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  • Maxillary mesenchymal chondrosarcoma leading to a diagnosis of Li-Fraumeni syndrome
    Publication . Ventura, Eduardo; Dionísio, Sílvia; Ferreira, Ângela; Saleiro, Rute; Marques, Hugo; Magalhães, Manuel; Monteiro, Carlos
    Mesenchymal chondrosarcoma (MCS) is a rare histological variant of chondrosarcoma, with aggressive behaviour. Due to the unique nature of this disease, management strategies are not well established. Li-Fraumeni syndrome (LFS) is a rare cancer predisposition syndrome with a wide tumour spectrum, associated with TP53 germline mutations. We report a case of MCS of the maxilla, treated with surgical excision and adjuvant chemotherapy, in a patient with a past medical history of choroid plexus papilloma and a family history of early age first-degree cervical uterine cancer, that led to the clinical suspicion of a cancer predisposition syndrome and the subsequent diagnosis of LFS. This is the first MCS described in a LFS case. It demonstrates that adjuvant chemotherapy should be considered, in conjunction with surgical excision, in MCS and that cancer predisposition syndromes should be suspected in patients with multiple neoplasms and a strong family history of cancer.
    2020Journal article Open access Show more
  • Metastatic Myoepithelial Carcinoma Ex Pleomorphic Adenoma of the Sublingual Salivary Gland
    Publication . Ferreira, Ângela T; Gonçalves, Joana; Ferreira, Andreia; Brandão, José Ricardo; Saleiro, Rute
    Myoepithelial carcinoma ex pleomorphic adenoma is a very rare malignant neoplasm of the salivary gland. Owing to its rarity, its clinical features and treatment are not well characterized. We describe a case of a patient who was referred to our department with a six-month history of a bulge on the right side of the floor of the mouth and a submandibular mass with progressive enlargement. The mass was resected, and an elective level I neck dissection was performed. Histological examination revealed myoepithelial carcinoma ex pleomorphic adenoma of the sublingual salivary gland. Thoracic computed tomography and biopsy revealed lung metastases. The patient died two years after the diagnosis
    2023-06Journal article Open access Show more
  • Parapharyngeal schwannoma—a challenging case report
    Publication . Monteiro, Carlos; Saleiro, Rute; Ventura, Eduardo; Dionísio, Sílvia; Ferreira, Ângela
    Parapharyngeal space primary neoplasias are infrequent findings in clinics, and schwannoma derived from a peripheral nerve is even rarer in this anatomic area [1]. The presented case is a patient who was referred to our department with a 3 months progressive soft palate enlargement without related symptoms. The challenge, in these cases, due to the anatomic complex area, is to catch a suitable approach to remove the tumor, according to dimension and surrounding structures. Prognosis and follow-up will depend on histopathologic evaluation.
    2020Journal article Open access Show more