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Browsing by Author "Sotgiu, G."

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  • Atypical pathogens in hospitalized patients with community-acquired pneumonia: a worldwide perspective
    Publication . Gramegna, A.; Sotgiu, G.; Di Pasquale, M.; Radovanovic, D.; Terraneo, S.; Reyes, L.; Vendrell, E.; Neves, J.; Menzella, F.; Blasi, F.; Aliberti, S.; Restrepo, M.
    BACKGROUND: Empirical antibiotic coverage for atypical pathogens in community-acquired pneumonia (CAP) has long been debated, mainly because of a lack of epidemiological data. We aimed to assess both testing for atypical pathogens and their prevalence in hospitalized patients with CAP worldwide, especially in relation with disease severity. METHODS: A secondary analysis of the GLIMP database, an international, multicentre, point-prevalence study of adult patients admitted for CAP in 222 hospitals across 6 continents in 2015, was performed. The study evaluated frequency of testing for atypical pathogens, including L. pneumophila, M. pneumoniae, C. pneumoniae, and their prevalence. Risk factors for testing and prevalence for atypical pathogens were assessed through univariate analysis. RESULTS: Among 3702 CAP patients 1250 (33.8%) underwent at least one test for atypical pathogens. Testing varies greatly among countries and its frequency was higher in Europe than elsewhere (46.0% vs. 12.7%, respectively, p < 0.0001). Detection of L. pneumophila urinary antigen was the most common test performed worldwide (32.0%). Patients with severe CAP were less likely to be tested for both atypical pathogens considered together (30.5% vs. 35.0%, p = 0.009) and specifically for legionellosis (28.3% vs. 33.5%, p = 0.003) than the rest of the population. Similarly, L. pneumophila testing was lower in ICU patients. At least one atypical pathogen was isolated in 62 patients (4.7%), including M. pneumoniae (26/251 patients, 10.3%), L. pneumophila (30/1186 patients, 2.5%), and C. pneumoniae (8/228 patients, 3.5%). Patients with CAP due to atypical pathogens were significantly younger, showed less cardiovascular, renal, and metabolic comorbidities in comparison to adult patients hospitalized due to non-atypical pathogen CAP. CONCLUSIONS: Testing for atypical pathogens in patients admitted for CAP in poorly standardized in real life and does not mirror atypical prevalence in different settings. Further evidence on the impact of atypical pathogens, expecially in the low-income countries, is needed to guidelines implementation.
    2018-12-18Journal article Open access Show more
  • Bacterial etiology of community-acquired pneumonia in immunocompetent hospitalized patients and appropriateness of empirical treatment recommendations: an international point-prevalence study
    Publication . Carugati, Manuela; Aliberti, S.; Sotgiu, G.; Blasi, F.; Gori, A.; Menendez, R.; Encheva, M.; Gallego, M.; Leuschner, P.; Ruiz-Buitrago, S.; Battaglia, S.; Fantini, R.; Pascual-Guardia, S.; Marin-Corral, J.; Restrepo, M. I.; Aruj, Patricia Karina; Attorri, Silvia; Barimboim, Enrique; Caeiro, Juan Pablo; Garzón, María I; Cambursano, Victor Hugo; Ceccato, Adrian; Chertcoff, Julio; Lascar, Florencia; Tulio, Fernando Di; Díaz, Ariel Cordon; de Vedia, Lautaro; Ganaha, Maria Cristina; Lambert, Sandra; Lopardo, Gustavo; Luna, Carlos M; Malberti, Alessio Gerardo; Morcillo, Nora; Tartara, Silvina; Pensotti, Claudia; Pereyra, Betiana; Scapellato, Pablo Gustavo; Stagnaro, Juan Pablo; Shah, Sonali; Lötsch, Felix; Thalhammer, Florian; Vincent, Jean Louis; Anseeuw, Kurt; Francois, Camille A; Van Braeckel, Eva; Djimon, Marcel Zannou; Bashi, Jules; Roger, Dodo; Nouér, Simone Aranha; Chipev, Peter; Encheva, Milena; Miteva, Darina; Petkova, Diana; Dodo, Balkissou Adamou; Ngahane, Mbatchou; Hugo, Bertrand; Shen, Ning; Xu, Jin-fu; Rico, Carlos Andres Bustamante; Buitrago, Ricardo; Paternina, Fernando Jose Pereira; Jean-Marie, Kayembe Ntumba; Carevic, Vesna Vladic; Jakopovic, Marko; Jankovic, Mateja; Matkovic, Zinka; Mitrecic, Ivan; Jacobsson, Marie-Laure Bouchy; Christensen, Anette Bro; HeitmannBødtger, Uff e Christian; Meyer, Christian Niels; Jensen, Andreas Vestergaard; Baunbæk-knudsen, Gertrud; Petersen, Pelle Trier; Andersen, Stine; El-Wahhab, Ibrahim El-Said Abd; Morsy, Nesreen Elsayed; Shafiek, Hanaa; Sobh, Eman; Bertrand, Fabrice; Brun-Buisson, Christian; de Montmollin, Etienne; Fartoukh, Muriel; Messika, Jonathan; Tattevin, Pierre; Dreher, Michael; Kolditz, Martin; Meisinger, Matthias; Pletz, Mathias W; Hagel, Stefan; Rupp, Jan; Schaberg, Tom; Spielmanns, Marc; Siaw-Lartey, Beatrice; Dimakou, Katerina; Papapetrou, Dimosthenis; Tsigou, Evdoxia; Ampazis, Dimitrios; Bhatia, Mohit; Dhar, Raja; D’Souza, George; Garg, Rajiv; Koul, Parvaiz A; Mahesh, P A; Jayaraj, B S; Narayan, Kiran Vishnu; Udnur, Hirennappa B; Krishnamurthy, Shashi Bhaskara; Golshani, Keihan; Keatings, Vera M; Martin-Loeches, Ignacio; Maor, Yasmin; Strahilevitz, Jacob; Battaglia, Salvatore; Carrabba, Maria; Ceriana, Piero; Confalonieri, Marco; d’Arminio Monforte, Antonella; Del Prato, Bruno; De Rosa, Marino; Fantini, Riccardo; Fiorentino, Giuseppe; Gammino, Maria Antonia; Menzella, Francesco; Milani, Giuseppe; Nava, Stefano; Palmiero, Gerardo; Petrino, Roberta; Gabrielli, Barbra; Rossi, Paolo; Sorino, Claudio; Steinhilber, Gundi; Zanforlin, Alessandro; Kurahashi, Kiyoyasu; Bacha, Zeina Aoun; Ugalde, Daniel Barajas; Zuñiga, Omar Ceballos; Villegas, José F; Medenica, Milic; van de Garde, E M W; Mihsra, Deebya Raj; Shrestha, Poojan; Ridgeon, Elliott; Awokola, Babatunde Ishola; Nwankwo, Ogonna N O; Olufunlola, Adefuye Bolanle; Olumide, Segaolu; Ukwaja, Kingsley N; Irfan, Muhammad; Minarowski, Lukasz; Szymon, Skoczyński; Froes, Felipe; Leuschner, Pedro; Meireles, Mariana; Ferrão, Cláudia; Leuschner, Pedro; Neves, João; Ravara, Sofia B; da Beira, Cova; Brocovschii, Victoria; Ion, Chesov; Rusu, Doina; Toma, Cristina; Chirita, Daniela; Birkun, Alexei; Kaluzhenina, Anna; Almotairi, Abdullah; Abdulbaqi, Zakeya; Bukhary, Ali; Edathodu, Jameela; Fathy, Amal; Enani, Abdullah Mushira Abdulaziz; Mohamed, Nazik Eltayeb; Memon, Jawed Ulhadi; Bogdanović, Nada; Milenkovic, Branislava; Pesut, Dragica; Borderìas, Luis; Garcia, Noel Manuel Bordon; Alarcón, Hugo Cabello; Cilloniz, Catia; Torres, Antoni; Diaz-Brito, Vicens; Casas, Xavier; González, Alicia Encabo; Fernández-Almira, Maria Luisa; Gallego, Miguel; Gaspar-GarcÍa, Inmaculada; del Castillo, Juan González; Victoria, Patricia Javaloyes; Martínez, Elena Laserna; de Molina, Rosa Malo; Marcos, Pedro J; Menéndez, Rosario; PandoSandova, Ana; Aymerich, Cristina Prat; del la Torre, Alicia Lacoma; García-Olivé, Ignasi; Rello, Jordi; Moyano, Silvia; Sanz, Francisco; Sibila, Oriol; Rodrigo-Troyano, Ana; Solé-Violán, Jordi; Uranga, Ane; van Boven, Job FM; Torra, Ester Vendrell; Pujol, Jordi Almirall; Feldman, Charles; Yum, Ho Kee; Fiogbe, Arnauld Attannon; Yangui, Ferdaous; Bilaceroglu, Semra; Dalar, Levent; Yilmaz, Ufuk; Bogomolov, Artemii; Elahi, Naheed; Dhasmana, Devesh J; Ions, Rhiannon; Skeemer, Julie; Woltmann, Gerrit; Hancock, Carole; Hill, Adam T; Rudran, Banu; Ruiz-Buitrago, Silvia; Campbell, Marion; Whitaker, Paul; Allen, Karen S; Brito, Veronica; Dietz, Jessica; Dysart, Claire E; Kellie, Susan M; Franco-Sadud, Ricardo A; Meier, Garnet; Gaga, Mina; Holland, Thomas L; Bergin, Stephen P; Kheir, Fayez; Landmeier, Mark; Lois, Manuel; Nair, Girish B; Patel, Hemali; Reyes, Katherine; Rodriguez-Cintron, William; Saito, Shigeki; Soni, Nilam J; Noda, Julio; Hinojosa, Cecilia I; Levine, Stephanie M; Angel, Luis F; Anzueto, Antonio; Whitlow, K Scott; Hipskind, John; Sukhija, Kunal; Wunderink, Richard G.; Shah, Ray D; Mateyo, Kondwelani John
    An accurate knowledge of the epidemiology of community-acquired pneumonia (CAP) is key for selecting appropriate antimicrobial treatments. Very few etiological studies assessed the appropriateness of empiric guideline recommendations at a multinational level. This study aims at the following: (i) describing the bacterial etiologic distribution of CAP and (ii) assessing the appropriateness of the empirical treatment recommendations by clinical practice guidelines (CPGs) for CAP in light of the bacterial pathogens diagnosed as causative agents of CAP. Secondary analysis of the GLIMP, a point-prevalence international study which enrolled adults hospitalized with CAP in 2015. The analysis was limited to immunocompetent patients tested for bacterial CAP agents within 24 h of admission. The CAP CPGs evaluated included the following: the 2007 and 2019 American Thoracic Society/Infectious Diseases Society of America (ATS/IDSA), the European Respiratory Society (ERS), and selected country-specific CPGs. Among 2564 patients enrolled, 35.3% had an identifiable pathogen. Streptococcus pneumoniae (8.2%) was the most frequently identified pathogen, followed by Pseudomonas aeruginosa (4.1%) and Klebsiella pneumoniae (3.4%). CPGs appropriately recommend covering more than 90% of all the potential pathogens causing CAP, with the exception of patients enrolled from Germany, Pakistan, and Croatia. The 2019 ATS/IDSA CPGs appropriately recommend covering 93.6% of the cases compared with 90.3% of the ERS CPGs (p < 0.01). S. pneumoniae remains the most common pathogen in patients hospitalized with CAP. Multinational CPG recommendations for patients with CAP seem to appropriately cover the most common pathogens and should be strongly encouraged for the management of CAP patients.
    2020Journal article Open access Show more