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  • Intraclonal diversity in a Sezary syndrome with a differential response to 2‐deoxycoformycin of the two lymphoma cell populations
    Publication . GRANJO, E.; LIMA, M.; LOPES, J.M.; CUNHA, N.; TEIXEIRA, M. A.; SANTOS, F.; CANDEIAS, J.; RESENDE, C.; SANTOS, A.H.; BALANZATEGUI, A.; ORFAO, A.; MATUTES, E.
    Br J Haematol. 2002 Dec;119(3):629-33. Intraclonal diversity in a Sezary syndrome with a differential response to 2-deoxycoformycin of the two lymphoma cell populations. Granjo E, Lima M, Lopes JM, Cunha N, Teixeira Mdos A, Santos F, Candeias J, Resende C, Santos AH, Balanzategui A, Orfão A, Matutes E. Department of Clinical Haematology, Hospital Geral de São João, Porto, Portugal. npp46740@mail.telpac.pt Abstract We report a case of Sezary syndrome with two abnormal CD4+ T-cell populations detected in the peripheral blood by flow cytometry immunophenotyping and DNA cell content, suggesting a biclonal T-cell lymphoproliferative disorder. Despite these findings, molecular analysis of the T-cell receptor genes was consistent with a monoclonal T-cell proliferation, supporting the existence of intraclonal diversity rather than a true biclonal disease. The patient achieved a transient response with 2-deoxycoformycin, with a selective decrease of the larger/hyperploid T-cell population; later on, an increased representation of this T-cell population was observed concomitantly with clinical relapse. PMID: 12437636 [PubMed - indexed for MEDLINE]
    2002-12Journal article Open access Show more
  • Three years incidence of dermatophytes in a hospital in Porto (Portugal)
    Publication . LOPES, V.; VELHO, G.; AMORIM, M.L.; CARDOSO, M.L.; MASSA, A.; AMORIM, J.M.
    Rev Iberoam Micol. 2002 Dec;19(4):201-3. [Three years incidence of dermatophytes in a hospital in Porto (Portugal)]. [Article in Spanish] Lopes V, Velho G, Amorim ML, Cardoso ML, Massa A, Amorim JM. SourceServiço de Microbiologia, Hospital Geral Santo António, Largo Prof. Abel Salazar, 4099-001 Porto, Portugal. Abstract We evaluated the incidence of dermatophytes isolated at our hospital in the years of 1997 to 2000 and correlated it with anatomical site and age. Trichophyton rubrum was the predominant species in all anatomical sites, excluding scalp, followed by Microsporum canis, the leading agent of tinea capitis. All dermatophytosis, except tinea capitis by M. canis and Trichophyton schoenleinnii appeared mainly in adult patients. Our results revealed no substantial differences to other portuguese studies regarding the major agents. We found a relatively high incidence of T. schoenleinnii as second tinea capitis agent.
    2002-12Journal article Open access Show more