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Exosomes isolation and characterization in serum is feasible in non-small cell lung cancer patients: critical analysis of evidence and potential role in clinical practice

dc.contributor.authorTaverna, S.
dc.contributor.authorGiallombardo, M.
dc.contributor.authorGil-Bazo, I.
dc.contributor.authorCarreca, A.
dc.contributor.authorCastiglia, M.
dc.contributor.authorChacártegui, J.
dc.contributor.authorAraujo, A.
dc.contributor.authorAlessandro, R.
dc.contributor.authorPauwels, P.
dc.contributor.authorPeeters, M.
dc.contributor.authorRolfo, C.
dc.date.accessioned2017-07-11T10:32:56Z
dc.date.available2017-07-11T10:32:56Z
dc.date.issued2016-05-10
dc.description.abstractExosomes are nano-sized vesicles of endolysosomal origin, released by several cytotypes in physiological and pathological conditions. Tumor derived exosomes, interacting with other cells of the tumor microenvironment, modulate tumor progression, angiogenic switch, metastasis, and immune escape. Recently, extracellular vesicles were proposed as excellent biomarkers for disease monitoring and prognosis in cancer patients. Non-small cell lung cancer (NSCLC) has a poor 5-year survival rate due to the delay in the detection of the disease. The majority of patients are diagnosed in an advanced disease stage. Exosomes might be promising beneficial tools as biomarker candidates in the scenario of NSCLC, since they contain both, proteins and miRNAs. The clinical case reported in this manuscript is a proof of concept revealing that NSCLC exosomes and sorted miRNAs might constitute, in a near future, novel biomarkers. This review summarizes the role of exosomes in NSCLC, focusing on the importance of exosomal microRNAs in lung cancer diagnosis and prognosis.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationOncotarget. 2016 May 10;7(19):28748-60pt_PT
dc.identifier.doi10.18632/oncotarget.7638pt_PT
dc.identifier.issn1949-2553
dc.identifier.urihttp://hdl.handle.net/10400.16/2144
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherImpact Journalspt_PT
dc.relation.publisherversionhttp://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=7638&pubmed-linkout=1pt_PT
dc.subjectNSCLCpt_PT
dc.subjectbiomarkerspt_PT
dc.subjectexosomespt_PT
dc.subjectliquid biopsiespt_PT
dc.subjectmicroRNAspt_PT
dc.titleExosomes isolation and characterization in serum is feasible in non-small cell lung cancer patients: critical analysis of evidence and potential role in clinical practicept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceUnited States of Americapt_PT
oaire.citation.endPage28760pt_PT
oaire.citation.issue19pt_PT
oaire.citation.startPage28748-60pt_PT
oaire.citation.titleOncotargetpt_PT
oaire.citation.volume7pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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