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Apolipoprotein B and non-high-density lipoprotein cholesterol reveal a high atherogenicity in individuals with type 2 diabetes and controlled low-density lipoprotein-cholesterol

2020-06-06Journal article Open access
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dc.contributor.authorFonseca, Liliana
dc.contributor.authorParedes, Sílvia
dc.contributor.authorRamos, Helena
dc.contributor.authorOliveira, José Carlos
dc.contributor.authorPalma, Isabel
dc.date.accessioned2022-03-31T09:29:22Z
dc.date.available2022-03-31T09:29:22Z
dc.date.issued2020-06-06
dc.description.abstractBackground: Lipid-lowering therapy is guided by Low-density-lipoprotein cholesterol (LDL-c) levels, although the cardiovascular disease (CVD) risk could be better reflected by other lipid parameters. This study aimed at comparing a comprehensive lipid profile between patients with type 2 diabetes mellitus (T2DM) with LDL-c concentration within and above target. Methods: A comprehensive lipid profile was characterized in 96 T2DM patients. The European Society of Cardiology/European Atherosclerosis Society (ESC/EAS) 2016 and 2019 Guidelines for the Management of Dyslipidemias were used to define LDL-c targets. Results: In this population, only 28.1 and 16.7% of patients had mean LDL-c levels within target, as defined by the 2016 and 2019 guidelines, respectively. Applying the 2016 guidelines criteria, in patients with LDL-c within target, 22, 25 and 44% presented non-high-density lipoprotein cholesterol (non-HDL-c), Apolipoprotein B (ApoB) and oxidized LDL-c levels above the recommended range, respectively, whereas according to the 2019 guidelines criteria, 50, 39 and 44% of the patients with LDL-c within target had elevated high-density lipoprotein cholesterol (HDL-c), ApoB and oxidized LDL-c levels, respectively. LDL-c was strongly correlated with non-HDL-c (r = 0.850), ApoB (r = 0.656) and oxidized LDL-c (r = 0.508). Similarly, there was a strong correlation between non-HDL-c with both ApoB (r = 0.808) and oxidized LDL-c (r = 0.588). Conclusions: These findings emphasize the limitations of only considering LDL-c concentration for cardiovascular (CV) risk assessment. Targeting only LDL-c could result in missed opportunities for CV risk reduction in T2DM patients. These data suggest that non-HDL-c, ApoB and oxidized LDL-c levels could be considered as an important part of these patients' evaluation allowing for a more accurate estimation of CV risk and hopefully better management of these high-risk patients.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFonseca L, Paredes S, Ramos H, Oliveira JC, Palma I. Apolipoprotein B and non-high-density lipoprotein cholesterol reveal a high atherogenicity in individuals with type 2 diabetes and controlled low-density lipoprotein-cholesterol. Lipids Health Dis. 2020;19(1):127.doi:10.1186/s12944-020-01292-wpt_PT
dc.identifier.doi10.1186/s12944-020-01292-wpt_PT
dc.identifier.issn1476-511X
dc.identifier.urihttp://hdl.handle.net/10400.16/2677
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBioMed Centralpt_PT
dc.relation.publisherversionhttps://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01292-wpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectApoBpt_PT
dc.subjectCV riskpt_PT
dc.subjectCVDpt_PT
dc.subjectDyslipidemiapt_PT
dc.subjectLDL-cpt_PT
dc.subjectNon-HDL cholesterolpt_PT
dc.subjectT2DMpt_PT
dc.titleApolipoprotein B and non-high-density lipoprotein cholesterol reveal a high atherogenicity in individuals with type 2 diabetes and controlled low-density lipoprotein-cholesterolpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceEnglandpt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage127pt_PT
oaire.citation.titleLipids in Health and Diseasept_PT
oaire.citation.volume19pt_PT
person.familyNameFonseca
person.familyNameOliveira
person.givenNameLiliana
person.givenNameJosé Carlos
person.identifier806053
person.identifier.ciencia-id801F-D4FE-8694
person.identifier.orcid0000-0002-3318-8308
person.identifier.orcid0000-0003-2142-6839
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationcbbbb354-fd2c-42a2-89a9-1cc07b04e207
relation.isAuthorOfPublicationbd6d8008-2622-4368-8ded-4ec1c1160c82
relation.isAuthorOfPublication.latestForDiscoverybd6d8008-2622-4368-8ded-4ec1c1160c82

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