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Abstract(s)
The World Health Organisation classification of mature T-cell lymphoproliferative disorders, combines
clinical, morphological and immunophenotypic data. The later majorly contributes for the classification, as
well as to the understanding of the malignant T-cell behaviour. The fact that T-cell migration is regulated by
chemokines should, in theory, enable us to identify tissue tropism and organ involvement by neoplastic Tcells,
through monitoring of chemokine receptor surface expression.
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Centro Hospitalar do Porto