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The Role of Multimodal Approach in the Assessment of Glaucomatous Damage in High Myopes

2021-03Journal article Open access
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dc.contributor.authorBaptista, Pedro Manuel
dc.contributor.authorVieira, Rita
dc.contributor.authorFerreira, André
dc.contributor.authorFigueiredo, Ana
dc.contributor.authorSampaio, Isabel
dc.contributor.authorReis, Rita
dc.contributor.authorMenéres, Maria João
dc.date.accessioned2023-10-19T11:30:44Z
dc.date.available2023-10-19T11:30:44Z
dc.date.issued2021-03
dc.description.abstracturpose: To compare the optic disc structure and peripapillary retinal function between high myopes with and without glaucoma and to address the differential role of papillary optical coherence tomography angiography (OCT-A) and circumpapillary microperimetry (cpMP) on the diagnosis and prognosis of this patients. Patients and methods: It is a cross-sectional study including 30 high myopic patients (60 eyes), divided into 15 with (GG) and 15 without glaucoma (NGG). Demographic and clinical data were collected from patient records. Papillary structure (peripapillary retinal nerve fiber layer thickness, ppRNFLTs) and vascularization (small vessel densities, SVD´s) were assessed with SD-OCT (RTVue XR Avanti, with AngioVue system, Optovue®). cpMP was carried out with the MP-3 microperimeter (Nidek®). Results: The GG were older, had lower best-corrected visual acuities and higher intraocular pressures and axial lengths (p<0.001). The GG showed lower values in all ppRNFLTs (p<0.05), lower values in all SVDs (p<0.001), except the SVD-inside disc (p=0.638) and lower retinal sensitivities within all cpMPs (p<0.001). The adjusted analysis computing the best two parameters per exam revealed that the anatomical model including the ppRNFLT-inferior and ppRNFLT-temporal and the vascular model including SVD-inferior and SVD-superior had the best discrimination power between groups, with cross-validated AUROCs of 0.9599 and 0.9921, respectively. Conclusion: Despite the apparent superiority of the papillary vascular study, a multimodal approach including the papillary anatomic and circumpapillary microperimetric assessments can be the new way on the diagnosis and prognosis of glaucoma in high myopia.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBaptista PM, Vieira R, Ferreira A, et al. The Role of Multimodal Approach in the Assessment of Glaucomatous Damage in High Myopes. Clin Ophthalmol. 2021;15:1061-1071. doi:10.2147/OPTH.S301781pt_PT
dc.identifier.doi10.2147/OPTH.S301781pt_PT
dc.identifier.issn1177-5467
dc.identifier.issn1177-5483
dc.identifier.urihttp://hdl.handle.net/10400.16/2824
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherDove Medical Presspt_PT
dc.relation.publisherversionhttps://www.dovepress.com/the-role-of-multimodal-approach-in-the-assessment-of-glaucomatous-dama-peer-reviewed-fulltext-article-OPTHpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectcircumpapillary microperimetrypt_PT
dc.subjectglaucomapt_PT
dc.subjecthigh myopiapt_PT
dc.subjectoptic disc dysgenesispt_PT
dc.subjectpapillary optical coherence tomography giographypt_PT
dc.subjectperipapillary retinal nerve fiber layer thicknesspt_PT
dc.titleThe Role of Multimodal Approach in the Assessment of Glaucomatous Damage in High Myopespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceNew Zealandpt_PT
oaire.citation.endPage1071pt_PT
oaire.citation.startPage1061pt_PT
oaire.citation.titleClinical Ophthalmologypt_PT
oaire.citation.volumeVolume 15pt_PT
person.familyNameBaptista
person.familyNameVieira
person.givenNamePedro Manuel
person.givenNameRita
person.identifier.orcid0000-0001-8285-1084
person.identifier.orcid0000-0002-5309-6347
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationaefa59ff-77f9-42ff-ac9b-88373f5c2ac8
relation.isAuthorOfPublicationcd1e83a1-7323-4dae-88ce-745f01b6b609
relation.isAuthorOfPublication.latestForDiscoverycd1e83a1-7323-4dae-88ce-745f01b6b609

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