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Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs
dc.contributor.author | Bastard, Paul | |
dc.contributor.author | Vazquez, Sara E. | |
dc.contributor.author | Liu, Jamin | |
dc.contributor.author | Laurie, Matthew T. | |
dc.contributor.author | Wang, Chung Yu | |
dc.contributor.author | Gervais, Adrian | |
dc.contributor.author | Le Voyer, Tom | |
dc.contributor.author | Bizien, Lucy | |
dc.contributor.author | Zamecnik, Colin | |
dc.contributor.author | Philippot, Quentin | |
dc.contributor.author | Rosain, Jérémie | |
dc.contributor.author | Catherinot, Emilie | |
dc.contributor.author | Willmore, Andrew | |
dc.contributor.author | Mitchell, Anthea M. | |
dc.contributor.author | Bair, Rebecca | |
dc.contributor.author | Garçon, Pierre | |
dc.contributor.author | Kenney, Heather | |
dc.contributor.author | Fekkar, Arnaud | |
dc.contributor.author | Salagianni, Maria | |
dc.contributor.author | Poulakou, Garyphallia | |
dc.contributor.author | Siouti, Eleni | |
dc.contributor.author | Sahanic, Sabina | |
dc.contributor.author | Tancevski, Ivan | |
dc.contributor.author | Weiss, Günter | |
dc.contributor.author | Nagl, Laurenz | |
dc.contributor.author | Manry, Jérémy | |
dc.contributor.author | Duvlis, Sotirija | |
dc.contributor.author | Arroyo-Sánchez, Daniel | |
dc.contributor.author | Paz Artal, Estela | |
dc.contributor.author | Rubio, Luis | |
dc.contributor.author | Perani, Cristiano | |
dc.contributor.author | Bezzi, Michela | |
dc.contributor.author | Sottini, Alessandra | |
dc.contributor.author | Quaresima, Virginia | |
dc.contributor.author | Roussel, Lucie | |
dc.contributor.author | Vinh, Donald C. | |
dc.contributor.author | Reyes, Luis Felipe | |
dc.contributor.author | Garzaro, Margaux | |
dc.contributor.author | Hatipoglu, Nevin | |
dc.contributor.author | Boutboul, David | |
dc.contributor.author | Tandjaoui-Lambiotte, Yacine | |
dc.contributor.author | Borghesi, Alessandro | |
dc.contributor.author | Aliberti, Anna | |
dc.contributor.author | Cassaniti, Irene | |
dc.contributor.author | Venet, Fabienne | |
dc.contributor.author | Monneret, Guillaume | |
dc.contributor.author | Halwani, Rabih | |
dc.contributor.author | Sharif-Askari, Narjes Saheb | |
dc.contributor.author | Danielson, Jeffrey | |
dc.contributor.author | Burrel, Sonia | |
dc.contributor.author | Morbieu, Caroline | |
dc.contributor.author | Stepanovskyy, Yurii | |
dc.contributor.author | Bondarenko, Anastasia | |
dc.contributor.author | Volokha, Alla | |
dc.contributor.author | Boyarchuk, Oksana | |
dc.contributor.author | Gagro, Alenka | |
dc.contributor.author | Neuville, Mathilde | |
dc.contributor.author | Neven, Bénédicte | |
dc.contributor.author | Keles, Sevgi | |
dc.contributor.author | Hernu, Romain | |
dc.contributor.author | Bal, Antonin | |
dc.contributor.author | Novelli, Antonio | |
dc.contributor.author | Novelli, Giuseppe | |
dc.contributor.author | Saker, Kahina | |
dc.contributor.author | Ailioaie, Oana | |
dc.contributor.author | Antolí, Arnau | |
dc.contributor.author | Jeziorski, Eric | |
dc.contributor.author | Rocamora-Blanch, Gemma | |
dc.contributor.author | Teixeira, Carla | |
dc.contributor.author | Delaunay, Clarisse | |
dc.contributor.author | Lhuillier, Marine | |
dc.contributor.author | Le Turnier, Paul | |
dc.contributor.author | Zhang, Yu | |
dc.contributor.author | Mahevas, Matthieu | |
dc.contributor.author | Pan-Hammarström, Qiang | |
dc.contributor.author | Abolhassani, Hassan | |
dc.contributor.author | Bompoil, Thierry | |
dc.contributor.author | Dorgham, Karim | |
dc.contributor.author | Gorochov, Guy | |
dc.contributor.author | Laouenan, Cédric | |
dc.contributor.author | Rodríguez-Gallego, Carlos | |
dc.contributor.author | Ng, Lisa F. P. | |
dc.contributor.author | Renia, Laurent | |
dc.contributor.author | Pujol, Aurora | |
dc.contributor.author | Belot, Alexandre | |
dc.contributor.author | Raffi, François | |
dc.contributor.author | Allende, Luis M. | |
dc.contributor.author | Martinez-Picado, Javier | |
dc.contributor.author | Ozcelik, Tayfun | |
dc.contributor.author | Imberti, Luisa | |
dc.contributor.author | Notarangelo, Luigi D. | |
dc.contributor.author | Troya, Jesus | |
dc.contributor.author | Solanich, Xavier | |
dc.contributor.author | Zhang, Shen-Ying | |
dc.contributor.author | Puel, Anne | |
dc.contributor.author | Wilson, Michael R. | |
dc.contributor.author | Trouillet-Assant, Sophie | |
dc.contributor.author | Abel, Laurent | |
dc.contributor.author | Jouanguy, Emmanuelle | |
dc.contributor.author | Ye, Chun Jimmie | |
dc.contributor.author | Cobat, Aurélie | |
dc.contributor.author | Thompson, Leslie M. | |
dc.contributor.author | Andreakos, Evangelos | |
dc.contributor.author | Zhang, Qian | |
dc.contributor.author | Anderson, Mark S. | |
dc.contributor.author | Casanova, Jean-Laurent | |
dc.contributor.author | DeRisi, Joseph L. | |
dc.date.accessioned | 2024-07-23T09:09:36Z | |
dc.date.available | 2024-07-23T09:09:36Z | |
dc.date.issued | 2023 | |
dc.description.abstract | Life-threatening "breakthrough" cases of critical COVID-19 are attributed to poor or waning antibody (Ab) response to SARS-CoV-2 vaccines in individuals already at risk. Preexisting auto-Abs neutralizing type I IFNs underlie at least 15% of critical COVID-19 pneumonia cases in unvaccinated individuals; their contribution to hypoxemic breakthrough cases in vaccinated people is unknown. We studied a cohort of 48 individuals (aged 20 to 86 years) who received two doses of a messenger RNA (mRNA) vaccine and developed a breakthrough infection with hypoxemic COVID-19 pneumonia 2 weeks to 4 months later. Ab levels to the vaccine, neutralization of the virus, and auto-Abs to type I IFNs were measured in the plasma. Forty-two individuals had no known deficiency of B cell immunity and a normal Ab response to the vaccine. Among them, 10 (24%) had auto-Abs neutralizing type I IFNs (aged 43 to 86 years). Eight of these 10 patients had auto-Abs neutralizing both IFN-α2 and IFN-ω, whereas two neutralized IFN-ω only. No patient neutralized IFN-β. Seven neutralized type I IFNs at 10 ng/ml and three at 100 pg/ml only. Seven patients neutralized SARS-CoV-2 D614G and Delta efficiently, whereas one patient neutralized Delta slightly less efficiently. Two of the three patients neutralizing only type I IFNs at 100 pg/ml neutralized both D614G and Delta less efficiently. Despite two mRNA vaccine inoculations and the presence of circulating Abs capable of neutralizing SARS-CoV-2, auto-Abs neutralizing type I IFNs may underlie a notable proportion of hypoxemic COVID-19 pneumonia cases, highlighting the importance of this particularly vulnerable population. | pt_PT |
dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
dc.identifier.citation | Bastard P, Vazquez SE, Liu J, et al. Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs. Sci Immunol. 2023;8(90):eabp8966. doi:10.1126/sciimmunol.abp8966 | pt_PT |
dc.identifier.doi | 10.1126/sciimmunol.abp8966 | pt_PT |
dc.identifier.issn | 2470-9468 | |
dc.identifier.uri | http://hdl.handle.net/10400.16/3012 | |
dc.language.iso | eng | pt_PT |
dc.peerreviewed | yes | pt_PT |
dc.publisher | American Association for the Advancement of Science | pt_PT |
dc.relation.publisherversion | https://doi.org/10.1126/sciimmunol.abp8966 | pt_PT |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
dc.title | Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs | pt_PT |
dc.type | journal article | |
dspace.entity.type | Publication | |
oaire.citation.conferencePlace | United States of America | pt_PT |
oaire.citation.issue | 90 | pt_PT |
oaire.citation.startPage | eabp8966 | pt_PT |
oaire.citation.title | Science Immunology | pt_PT |
oaire.citation.volume | 8 | pt_PT |
rcaap.rights | openAccess | pt_PT |
rcaap.type | article | pt_PT |
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