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Acute Heart Failure Comorbidome: The Impact of Everything Else

2020-02-03Journal article Open access
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dc.contributor.authorMeireles, Mariana
dc.contributor.authorGonçalves, João
dc.contributor.authorNeves, João
dc.date.accessioned2021-06-09T13:52:32Z
dc.date.available2021-06-09T13:52:32Z
dc.date.issued2020-02-03
dc.description.abstractIntroduction: Heart failure frequently coexists with several comorbidities. Our aim is to evaluate the prognostic role of various comorbidities in the risk of acute heart failure development. Material and methods: Comorbidities of patients with acute heart failure were, retrospectively, compared to a control group of patients with chronic heart failure admitted to an Internal Medicine unit in a 2-year period. Logistic regression models were constructed to determine their association with acute heart failure and to develop a comorbidome. Results: We identified 229 patients with acute heart failure and 201 patients with chronic heart failure. Age and female gender were higher in acute heart failure group (p < 0.001) as was the number of comorbidities (4.0 ± 3.0 vs 4.0 ± 2.0, p = 0.044). Hyperuricemia (odds ratio 2.46, confidence interval 95% 1.41 - 4.31, p = 0.002), obesity (odds ratio 2.22, confidence interval 95% 1.31 - 3.76, p = 0.003), atrial fibrillation (odds ratio 1.93, confidence interval 95% 1.31 - 2.87, p = 0.001), peripheral artery disease (odds ratio 2.12, confidence interval 95% 1.01 - 4.42, p = 0.046) and chronic kidney disease (odds ratio 2.47, confidence interval 95% 1.65 - 3.71, p < 0.001) were associated with acute heart failure. Obesity, atrial fibrillation, peripheral artery disease and chronic kidney disease were identified as independent risk factors. Patients with multiple comorbidities had a superior risk of hospitalization due to heart failure: zero comorbidities - odds ratio 0.43, 95% confidence interval 0.28 - 0.67, p < 0.001; one comorbidity - odds ratio 0.69, 95% confidence interval 0.47 - 1.01, p = 0.057; two comorbidities - odds ratio 1.85, 95% confidence interval 1.11 - 3.08, p = 0.019; ≥ three comorbidities - odds ratio 5.81, 95% confidence interval 2.77 - 12.16, p < 0.001. Discussion: This study shows an association between several comorbidities and hospital admission due to acute heart failure. The association seems to strengthen in the presence of multiple comorbidities. Conclusion: A comorbidome is a useful tool to identify comorbidities associated with higher risk of acute heart failure. The identification of vulnerable patients may allow multidimensional interventions to minimize future hospital admissions.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMeireles MA, Golçalves J, Neves J. Acute Heart Failure Comorbidome: The Impact of Everything Else. Acta Med Port. 2020 Feb 3;33(2):109-115. doi: 10.20344/amp.11051. Epub 2020 Feb 3. PMID: 32035496.pt_PT
dc.identifier.doi10.20344/amp.11051pt_PT
dc.identifier.issn1646-0758
dc.identifier.urihttp://hdl.handle.net/10400.16/2469
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherCentro Editor Livreiro da Ordem dos Médicospt_PT
dc.relation.publisherversionhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/11051/5861pt_PT
dc.subjectComorbiditypt_PT
dc.subjectHeart Failurept_PT
dc.subjectHospitalizationpt_PT
dc.subjectMortalitypt_PT
dc.titleAcute Heart Failure Comorbidome: The Impact of Everything Elsept_PT
dc.title.alternativeComorbidoma na Insuficiência Cardíaca Aguda: O Impacto de Tudo o Restopt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlacePortugalpt_PT
oaire.citation.endPage115pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage109pt_PT
oaire.citation.titleActa medica portuguesapt_PT
oaire.citation.volume33pt_PT
person.familyNameMeireles
person.familyNameNeves
person.givenNameMariana
person.givenNameJoão
person.identifier.orcid0000-0002-5744-6738
person.identifier.orcid0000-0003-0967-8443
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationad35d4d2-715f-4b43-a457-d54f8c6cabea
relation.isAuthorOfPublication3bfd605b-450e-4b09-9086-cc41e458513b
relation.isAuthorOfPublication.latestForDiscovery3bfd605b-450e-4b09-9086-cc41e458513b

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