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Glycans as Key Checkpoints of T Cell Activity and Function
dc.contributor.author | Pereira, M. | |
dc.contributor.author | Alves, I. | |
dc.contributor.author | Vicente, M. | |
dc.contributor.author | Campar, A. | |
dc.contributor.author | Silva, M. | |
dc.contributor.author | Padrão, N. | |
dc.contributor.author | Pinto, V. | |
dc.contributor.author | Fernandes, Â. | |
dc.contributor.author | Dias, A. | |
dc.contributor.author | Pinho, S. | |
dc.date.accessioned | 2019-08-26T13:47:29Z | |
dc.date.available | 2019-08-26T13:47:29Z | |
dc.date.issued | 2018-11-27 | |
dc.description.abstract | The immune system is highly controlled and fine-tuned by glycosylation, through the addition of a diversity of carbohydrates structures (glycans) to virtually all immune cell receptors. Despite a relative backlog in understanding the importance of glycans in the immune system, due to its inherent complexity, remarkable findings have been highlighting the essential contributions of glycosylation in the regulation of both innate and adaptive immune responses with important implications in the pathogenesis of major diseases such as autoimmunity and cancer. Glycans are implicated in fundamental cellular and molecular processes that regulate both stimulatory and inhibitory immune pathways. Besides being actively involved in pathogen recognition through interaction with glycan-binding proteins (such as C-type lectins), glycans have been also shown to regulate key pathophysiological steps within T cell biology such as T cell development and thymocyte selection; T cell activity and signaling as well as T cell differentiation and proliferation. These effects of glycans in T cells functions highlight their importance as determinants of either self-tolerance or T cell hyper-responsiveness which ultimately might be implicated in the creation of tolerogenic pathways in cancer or loss of immunological tolerance in autoimmunity. This review discusses how specific glycans (with a focus on N-linked glycans) act as regulators of T cell biology and their implications in disease. | pt_PT |
dc.description.sponsorship | The Institute of Molecular Pathology and Immunology of the University of Porto integrates the i3S research unit, which is partially supported by the Portuguese Foundation for Science and Technology (FCT). This article is a result of the project NORTE-01-0145-FEDER-000029, supported by the Norte Portugal Regional Programme (NORTE 2020) under the PORTUGAL 2020 Partnership Agreement through the European Regional Development Fund. This work was also funded by Fundo Europeu de Desenvolvimento Regional (FEDER) funds through the COMPETE 2020—Operacional Programme for Competitiveness and Internationalization (POCI), Portugal 2020, and by Portuguese funds through the FCT in the framework of the project (POCI-01/ 0145-FEDER-016601 and PTDC/DTP-PIC/0560/2014, as well as POCI-01-0145-FEDER-028772). SSP acknowledges the European Crohn's and Colitis Organization (ECCO) for ECCO Grant 2017, the Broad Medical Research Program at the Crohn's and Colitis Foundation of America, and the Portuguese Group of Study in IBD (GEDII) for funding. MSP [SFRH/BD/110148/2015], IA [SFRH/BD/128874/2017], MV [PD/BD/135452/2017], received funding from the FC | pt_PT |
dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
dc.identifier.citation | Front Immunol. 2018 Nov 27;9:2754 | pt_PT |
dc.identifier.doi | 10.3389/fimmu.2018.02754 | pt_PT |
dc.identifier.issn | 1664-3224 | |
dc.identifier.uri | http://hdl.handle.net/10400.16/2285 | |
dc.language.iso | eng | pt_PT |
dc.peerreviewed | yes | pt_PT |
dc.publisher | Frontiers Media | pt_PT |
dc.relation.publisherversion | https://www.frontiersin.org/articles/10.3389/fimmu.2018.02754/full | pt_PT |
dc.subject | N-glycosylation | pt_PT |
dc.subject | glycans | pt_PT |
dc.subject | T cells | pt_PT |
dc.subject | immune response | pt_PT |
dc.subject | autoimmunity | pt_PT |
dc.subject | self-tolerance | pt_PT |
dc.title | Glycans as Key Checkpoints of T Cell Activity and Function | pt_PT |
dc.type | journal article | |
dspace.entity.type | Publication | |
oaire.citation.conferencePlace | Switzerland | pt_PT |
oaire.citation.startPage | 2754 | pt_PT |
oaire.citation.title | Frontiers in Immunology | pt_PT |
oaire.citation.volume | 9 | pt_PT |
rcaap.rights | openAccess | pt_PT |
rcaap.type | article | pt_PT |
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