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2023 ACR/EULAR antiphospholipid syndrome classification criteria

2023-10Journal article Open access
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dc.contributor.authorBarbhaiya, Medha
dc.contributor.authorZuily, Stephane
dc.contributor.authorNaden, Ray
dc.contributor.authorHendry, Alison
dc.contributor.authorManneville, Florian
dc.contributor.authorAmigo, Mary-Carmen
dc.contributor.authorAmoura, Zahir
dc.contributor.authorAndrade, Danieli
dc.contributor.authorAndreoli, Laura
dc.contributor.authorArtim-Esen, Bahar
dc.contributor.authorAtsumi, Tatsuya
dc.contributor.authorAvcin, Tadej
dc.contributor.authorBelmont, Michael H
dc.contributor.authorBertolaccini, Maria Laura
dc.contributor.authorBranch, D Ware
dc.contributor.authorCarvalheiras, Graziela
dc.contributor.authorCasini, Alessandro
dc.contributor.authorCervera, Ricard
dc.contributor.authorCohen, Hannah
dc.contributor.authorCostedoat-Chalumeau, Nathalie
dc.contributor.authorCrowther, Mark
dc.contributor.authorde Jesús, Guilherme
dc.contributor.authorDelluc, Aurelien
dc.contributor.authorDesai, Sheetal
dc.contributor.authorSancho, Maria De
dc.contributor.authorDevreese, Katrien M
dc.contributor.authorDiz-Kucukkaya, Reyhan
dc.contributor.authorDuarte-García, Ali
dc.contributor.authorFrances, Camille
dc.contributor.authorGarcia, David
dc.contributor.authorGris, Jean-Christophe
dc.contributor.authorJordan, Natasha
dc.contributor.authorLeaf, Rebecca K
dc.contributor.authorKello, Nina
dc.contributor.authorKnight, Jason S
dc.contributor.authorLaskin, Carl
dc.contributor.authorLee, Alfred I
dc.contributor.authorLegault, Kimberly
dc.contributor.authorLevine, Steve R
dc.contributor.authorLevy, Roger A
dc.contributor.authorLimper, Maarten
dc.contributor.authorLockshin, Michael D
dc.contributor.authorMayer-Pickel, Karoline
dc.contributor.authorMusial, Jack
dc.contributor.authorMeroni, Pier Luigi
dc.contributor.authorOrsolini, Giovanni
dc.contributor.authorOrtel, Thomas L
dc.contributor.authorPengo, Vittorio
dc.contributor.authorPetri, Michelle
dc.contributor.authorPons-Estel, Guillermo
dc.contributor.authorGomez-Puerta, Jose A
dc.contributor.authorRaimboug, Quentin
dc.contributor.authorRoubey, Robert
dc.contributor.authorSanna, Giovanni
dc.contributor.authorSeshan, Surya V
dc.contributor.authorSciascia, Savino
dc.contributor.authorTektonidou, Maria G
dc.contributor.authorTincani, Angela
dc.contributor.authorWahl, Denis
dc.contributor.authorWillis, Rohan
dc.contributor.authorYelnik, Cécile
dc.contributor.authorZuily, Catherine
dc.contributor.authorGuillemin, Francis
dc.contributor.authorCostenbader, Karen
dc.contributor.authorErkan, Doruk
dc.date.accessioned2024-07-18T11:08:27Z
dc.date.available2024-07-18T11:08:27Z
dc.date.issued2023-10
dc.description.abstractObjective: To develop new antiphospholipid syndrome (APS) classification criteria with high specificity for use in observational studies and trials, jointly supported by the American College of Rheumatology (ACR) and EULAR. Methods: This international multidisciplinary initiative included four phases: (1) Phase I, criteria generation by surveys and literature review; (2) Phase II, criteria reduction by modified Delphi and nominal group technique exercises; (3) Phase III, criteria definition, further reduction with the guidance of real-world patient scenarios, and weighting via consensus-based multicriteria decision analysis, and threshold identification; and (4) Phase IV, validation using independent adjudicators' consensus as the gold standard. Results: The 2023 ACR/EULAR APS classification criteria include an entry criterion of at least one positive antiphospholipid antibody (aPL) test within 3 years of identification of an aPL-associated clinical criterion, followed by additive weighted criteria (score range 1-7 points each) clustered into six clinical domains (macrovascular venous thromboembolism, macrovascular arterial thrombosis, microvascular, obstetric, cardiac valve, and hematologic) and two laboratory domains (lupus anticoagulant functional coagulation assays, and solid-phase enzyme-linked immunosorbent assays for IgG/IgM anticardiolipin and/or IgG/IgM anti-β2-glycoprotein I antibodies). Patients accumulating at least three points each from the clinical and laboratory domains are classified as having APS. In the validation cohort, the new APS criteria vs the 2006 revised Sapporo classification criteria had a specificity of 99% vs 86%, and a sensitivity of 84% vs 99%. Conclusion: These new ACR/EULAR APS classification criteria were developed using rigorous methodology with multidisciplinary international input. Hierarchically clustered, weighted, and risk-stratified criteria reflect the current thinking about APS, providing high specificity and a strong foundation for future APS research.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBarbhaiya M, Zuily S, Naden R, et al. 2023 ACR/EULAR antiphospholipid syndrome classification criteria. Ann Rheum Dis. 2023;82(10):1258-1270. doi:10.1136/ard-2023-224609pt_PT
dc.identifier.doi10.1136/ard-2023-224609pt_PT
dc.identifier.issn0003-4967
dc.identifier.issn1468-2060
dc.identifier.urihttp://hdl.handle.net/10400.16/3005
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBMJ Publishing Grouppt_PT
dc.relation.publisherversionhttps://ard.bmj.com/content/82/10/1258pt_PT
dc.subjectantibodiespt_PT
dc.subjectantiphospholipidpt_PT
dc.subjectantiphospholipid syndromept_PT
dc.subjectthrombosispt_PT
dc.title2023 ACR/EULAR antiphospholipid syndrome classification criteriapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceEnglandpt_PT
oaire.citation.endPage1270pt_PT
oaire.citation.issue10pt_PT
oaire.citation.startPage1258pt_PT
oaire.citation.titleAnnals of the Rheumatic Diseasespt_PT
oaire.citation.volume82pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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