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Neuropsychiatric Systemic Lupus Erythematosus Involvement: Towards a Tailored Approach to Our Patients?

2017-01-30Journal article Open access
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dc.contributor.authorFaria, R.
dc.contributor.authorGonçalves, J.
dc.contributor.authorDias, R.
dc.date.accessioned2017-08-29T11:27:56Z
dc.date.available2017-08-29T11:27:56Z
dc.date.issued2017-01-30
dc.description.abstractNeuropsychiatric involvement in systemic lupus erythematosus (NPSLE) is a complex condition that remains poorly understood, and includes heterogeneous manifestations involving both the central and peripheral nervous system, with disabling effects. There are several models to improve NPSLE diagnosis when a neurological syndrome is present. In the last couple of years, the growing knowledge of the role of cytokines and antibodies in NPSLE, as well as the development of new functional imaging techniques, has brought some insights into the physiopathology of the disease, but their validation for clinical use remains undetermined. Furthermore, besides the classic clinical approach, a new tool for screening the 19 NPSLE syndromes has also been developed. Regarding NPSLE therapeutics, there is still no evidence-based treatment approach, but some data support the safety of biological medication when classic treatment fails. Despite the tendency to reclassify SLE patients in clinical and immunological subsets, we hope that these data will inspire medical professionals to approach NPSLE in a manner more tailored to the individual patient.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRambam Maimonides Med J. 2017 Jan 30;8(1)pt_PT
dc.identifier.doi10.5041/RMMJ.10276pt_PT
dc.identifier.issn2076-9172
dc.identifier.urihttp://hdl.handle.net/10400.16/2168
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherRambam Heath Care Campuspt_PT
dc.relation.publisherversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5298362/pt_PT
dc.subjectAttribution modelspt_PT
dc.subjectfunctional magnetic resonance imagingpt_PT
dc.subjectneuropsychiatric systemic lupuspt_PT
dc.titleNeuropsychiatric Systemic Lupus Erythematosus Involvement: Towards a Tailored Approach to Our Patients?pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceIsraelpt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPagee0001pt_PT
oaire.citation.titleRambam Maimonides Medical Journalpt_PT
oaire.citation.volume8pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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