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Development and preliminary validation of the Behçet’s syndrome Overall Damage Index (BODI)

2020Journal article Open access
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dc.contributor.authorPiga, Matteo
dc.contributor.authorFloris, Alberto
dc.contributor.authorEspinosa, Gerard
dc.contributor.authorSerpa Pinto, Luísa
dc.contributor.authorKougkas, Nikolaos
dc.contributor.authorLo Monaco, Andrea
dc.contributor.authorLopalco, Giuseppe
dc.contributor.authorOrlando, Ida
dc.contributor.authorPirani, Vittorio
dc.contributor.authorSantos, Ernestina
dc.contributor.authorBertsias, George
dc.contributor.authorCantarini, Luca
dc.contributor.authorCauli, Alberto
dc.contributor.authorCervera, Ricard
dc.contributor.authorCorreia, João
dc.contributor.authorGovoni, Marcello
dc.contributor.authorIannone, Florenzo
dc.contributor.authorNeri, Piergiorgio
dc.contributor.authorMartins da Silva, Ana
dc.contributor.authorVasconcelos, Carlos
dc.contributor.authorMuntoni, Monica
dc.contributor.authorMathieu, Alessandro
dc.date.accessioned2022-07-12T12:47:54Z
dc.date.available2022-07-12T12:47:54Z
dc.date.issued2020
dc.description.abstractObjective: To develop and validate the evidence-based and consensus-based Behçet's Syndrome Overall Damage Index (BODI). Methods: Starting from 120 literature-retrieved preliminary items, the BODI underwent multiple Delphi rounds with an international multidisciplinary panel consisting of rheumatologists, internists, ophthalmologists, neurologists, and patient delegates until consensus was reached on the final content. The BODI was validated in a cross-sectional multicentre cohort of 228 patients with Behçet's syndrome (BS) through the study of (a) correlation between BODI and Vasculitis Damage Index (VDI) and (b) correlation between BODI and disease activity measures (ie, Behçet's Disease Current Activity Form (BDCAF), Physician Global Assessment (PGA), Patient Global Assessment (PtGA)), c) content and face validity and (d) feasibility. Results: The final BODI consists of 4 overarching principles and 46 unweighted-items grouped into 9 organ domains. It showed good to excellent reliability, with a mean Cohen's k of 0.84 (95% CI 0.78 to 0.90) and a mean intra-class correlation coefficient of 0.88 (95% CI 0.80 to 0.95). Overall, 128 (56.1%) patients had a BODI score ≥1, with a median score of 1.0 (range 0-14). The BODI significantly correlated with the VDI (r=0.693, p<0.001), demonstrating to effectively measure damage (construct validity), but had greater sensitivity in identifying major organ damage and did not correlate with disease activity measures (ie, BDCAF: p=0.807, PGA: p=0.820, PtGA: p=0.794) discriminating damage from the major confounding factor. The instrument was deemed credible (face validity), complete (content validity) and feasible by an independent group of clinicians. Conclusions: Pending further validation, the BODI may be used to assess organ damage in patients with BS in the context of observational and controlled trials.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPiga M, Floris A, Espinosa G, et al. Development and preliminary validation of the Behçet's syndrome Overall Damage Index (BODI). RMD Open. 2020;6(2):e001192. doi:10.1136/rmdopen-2020-001192pt_PT
dc.identifier.doi10.1136/rmdopen-2020-001192pt_PT
dc.identifier.issn2056-5933
dc.identifier.urihttp://hdl.handle.net/10400.16/2715
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBMJpt_PT
dc.relation.publisherversionhttps://rmdopen.bmj.com/content/6/2/e001192.longpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectBehcet’s diseasept_PT
dc.subjectOutcomes researchpt_PT
dc.subjectSystemic vasculitispt_PT
dc.titleDevelopment and preliminary validation of the Behçet’s syndrome Overall Damage Index (BODI)pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceEnglandpt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPagee001192pt_PT
oaire.citation.titleRMD Openpt_PT
oaire.citation.volume6pt_PT
person.familyNameSerpa Pinto
person.familyNameAzevedo Moreira dos Santos
person.familyNameMartins da Silva
person.givenNameLuísa
person.givenNameMaria Ernestina
person.givenNameAna
person.identifier.ciencia-id3F18-4F00-289B
person.identifier.ciencia-id1116-6606-5CF5
person.identifier.orcid0000-0001-5115-4905
person.identifier.orcid0000-0003-4053-8940
person.identifier.orcid0000-0002-1409-0831
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication9653846d-d3c7-4760-b306-0723c927ab22
relation.isAuthorOfPublicationf5ce2f3b-1eef-463b-86e8-6b946d7f2d6f
relation.isAuthorOfPublicatione2fd5aa2-f733-43eb-b339-14fcaa3d881d
relation.isAuthorOfPublication.latestForDiscovery9653846d-d3c7-4760-b306-0723c927ab22

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