Gait speed in clinical and daily living assessments in Parkinson’s disease patients: performance versus capacity

Atrsaei, Arash; Corrà, Marta; Dadashi, Farzin; Vila Cha, Nuno; Maia, Luis; Mariani, Benoit; Maetzler, Walter; Aminian, Kamiar

Publication

Gait speed in clinical and daily living assessments in Parkinson’s disease patients: performance versus capacity

2021-03Journal article

dc.contributor.author	Atrsaei, Arash
dc.contributor.author	Corrà, Marta
dc.contributor.author	Dadashi, Farzin
dc.contributor.author	Vila Cha, Nuno
dc.contributor.author	Maia, Luis
dc.contributor.author	Mariani, Benoit
dc.contributor.author	Maetzler, Walter
dc.contributor.author	Aminian, Kamiar
dc.date.accessioned	2023-10-17T13:07:29Z
dc.date.available	2023-10-17T13:07:29Z
dc.date.issued	2021-03
dc.description.abstract	Gait speed often referred as the sixth vital sign is the most powerful biomarker of mobility. While a clinical setting allows the estimation of gait speed under controlled conditions that present functional capacity, gait speed in real-life conditions provides the actual performance of the patient. The goal of this study was to investigate objectively under what conditions during daily activities, patients perform as well as or better than in the clinic. To this end, we recruited 27 Parkinson's disease (PD) patients and measured their gait speed by inertial measurement units through several walking tests in the clinic as well as their daily activities at home. By fitting a bimodal Gaussian model to their gait speed distribution, we found that on average, patients had similar modes in the clinic and during daily activities. Furthermore, we observed that the number of medication doses taken throughout the day had a moderate correlation with the difference between clinic and home. Performing a cycle-by-cycle analysis on gait speed during the home assessment, overall only about 3% of the strides had equal or greater gait speeds than the patients' capacity in the clinic. These strides were during long walking bouts (>1 min) and happened before noon, around 26 min after medication intake, reaching their maximum occurrence probability 3 h after Levodopa intake. These results open the possibility of better control of medication intake in PD by considering both functional capacity and continuous monitoring of gait speed during real-life conditions.	pt_PT
dc.description.version	info:eu-repo/semantics/publishedVersion	pt_PT
dc.identifier.citation	Atrsaei A, Corrà MF, Dadashi F, et al. Gait speed in clinical and daily living assessments in Parkinson's disease patients: performance versus capacity. NPJ Parkinsons Dis. 2021;7(1):24. Published 2021 Mar 5. doi:10.1038/s41531-021-00171-0	pt_PT
dc.identifier.doi	10.1038/s41531-021-00171-0	pt_PT
dc.identifier.issn	2373-8057
dc.identifier.uri	http://hdl.handle.net/10400.16/2819
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.publisher	Nature Publishing Group	pt_PT
dc.relation.publisherversion	https://www.nature.com/articles/s41531-021-00171-0	pt_PT
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	pt_PT
dc.title	Gait speed in clinical and daily living assessments in Parkinson’s disease patients: performance versus capacity	pt_PT
dc.type	journal article
dspace.entity.type	Publication
oaire.citation.conferencePlace	United States of America	pt_PT
oaire.citation.issue	1	pt_PT
oaire.citation.title	npj Parkinson's Disease	pt_PT
oaire.citation.volume	7	pt_PT
person.familyName	Corrà
person.familyName	Vila Cha
person.familyName	Maia
person.givenName	Marta Francisca
person.givenName	Nuno
person.givenName	Luis
person.identifier.ciencia-id	0A12-811C-0517
person.identifier.ciencia-id	9F1E-51AF-C38B
person.identifier.orcid	0000-0002-3457-2328
person.identifier.orcid	0000-0002-8140-3471
person.identifier.rid	J-1742-2014
rcaap.rights	openAccess	pt_PT
rcaap.type	article	pt_PT
relation.isAuthorOfPublication	f689aee6-8536-465d-b59c-7b1ad34e42a9
relation.isAuthorOfPublication	479a717d-b0d8-4700-9761-8f107ca2da22
relation.isAuthorOfPublication	2b17a107-4559-498c-82f9-559a1ded4cac
relation.isAuthorOfPublication.latestForDiscovery	479a717d-b0d8-4700-9761-8f107ca2da22