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Leprosy presenting as remitting seronegative symmetrical synovitis with pitting oedema syndrome - a case report

2019-05-22Journal article Open access
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dc.contributor.authorGuerra, M.
dc.contributor.authorVideira, T.
dc.contributor.authorMorais, H.
dc.contributor.authorSantos, T.
dc.contributor.authorTaipa, Ricardo
dc.contributor.authorAbreu, M.
dc.contributor.authorVieira
dc.contributor.authorda Fonseca
dc.contributor.authorDos Santos
dc.contributor.authorPinto
dc.date.accessioned2020-05-04T22:37:56Z
dc.date.available2020-05-04T22:37:56Z
dc.date.issued2019-05-22
dc.description.abstractBackground: Leprosy typically manifests with skin and peripheral nerve involvement. Musculoskeletal complaints are the third most common, and can be the sole presenting manifestation. They range from arthralgia/arthritis in reactional states to full mimics of systemic rheumatic diseases. Remitting Seronegative Symmetrical Synovitis with Pitting Oedema syndrome has only been described once in a patient with already diagnosed Leprosy. Case report: A 68-year-old male, from an endemic region of familial amyloid polyneuropathy, presented with an inaugural Remitting Seronegative Symmetrical Synovitis with Pitting Oedema like syndrome, more that 20 years after travelling to Leprosy endemic areas. Arthritis would resurface whenever oral prednisone was tapered, so methotrexate was started, controlling the complaints. Only one year later, after the appearance of peripheral neuropathy and skin lesions, it was possible to diagnose Leprosy, through the identification of Mycobacterium leprae bacilli in a peripheral nerve biopsy. Conclusion: This report is an example of the heterogeneity of manifestations of Leprosy, namely rheumatic, and the challenge of diagnosing it when typical complaints are absent. It is also a reminder that this disease should be considered whenever a patient with a combination of skin/neurologic/rheumatic complaints has travelled to endemic countries in the past.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGuerra MG, Videira TMFC, Morais HAG, et al. Leprosy presenting as remitting seronegative symmetrical synovitis with pitting oedema syndrome - a case report. BMC Infect Dis. 2019;19(1):455. Published 2019 May 22. doi:10.1186/s12879-019-4098-9pt_PT
dc.identifier.doi10.1186/s12879-019-4098-9pt_PT
dc.identifier.issn1471-2334
dc.identifier.urihttp://hdl.handle.net/10400.16/2357
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBMCpt_PT
dc.relation.publisherversionhttps://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-019-4098-9pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectLeprosypt_PT
dc.subjectPeripheral neuropathypt_PT
dc.subjectRemitting seronegative symmetrical synovitis with pitting Oedema syndromept_PT
dc.titleLeprosy presenting as remitting seronegative symmetrical synovitis with pitting oedema syndrome - a case reportpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceEnglandpt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage455pt_PT
oaire.citation.titleBMC infectious diseasespt_PT
oaire.citation.volume19pt_PT
person.familyNameFerreira Taipa
person.givenNameRicardo Jorge
person.identifier.ciencia-idE316-D53D-8537
person.identifier.orcid0000-0002-9260-0227
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication97a7bf34-226a-4dc2-ae31-d0f86030cb52
relation.isAuthorOfPublication.latestForDiscovery97a7bf34-226a-4dc2-ae31-d0f86030cb52

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