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Real-world retrospective comparison of 0.19 mg fluocinolone acetonide and 0.7 mg dexamethasone intravitreal implants for the treatment of diabetic macular edema in vitrectomized eyes

2019Journal article Open access
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dc.contributor.authorCoelho, João
dc.contributor.authorMalheiro, Luisa
dc.contributor.authorMelo Beirão, João
dc.contributor.authorMeireles, Angelina
dc.contributor.authorPessoa, Bernardete
dc.date.accessioned2020-05-06T22:43:34Z
dc.date.available2020-05-06T22:43:34Z
dc.date.issued2019
dc.description.abstractPurpose: The aim of this study was to evaluate the long-term real-world effectiveness of FAc and DEX implants in vitrectomized DME eyes in a real-world setting. Methods: This was a non-interventional, retrospective, comparative study of 46 vitrectomized eyes in 33 patients with persistent or recurrent DME quantified best-corrected visual acuity (BCVA), central foveal thickness (CFT) and intraocular pressure (IOP) over up to 37 months. Results: Both FAc and DEX treatment led to statistically and clinically significant improvements in BCVA and CFT. FAc >10-letter improvement on the Early Treatment Diabetic Retinopathy Study [ETDRS] chart over months 3-24 and a sustained ~200 µm CFT reduction over months 1-24; DEX: >5-letter improvement on the ETDRS chart at months 1 and 3 and >100 µm CFT reduction at month 1. FAc demonstrated sustained, stable and predictable effects on BCVA and CFT over 24 months and also improved BCVA and decreased CFT in a cohort of DME eyes that was refractory to DEX over 6 months. Conclusion: This real-world study demonstrates long-term effectiveness of FAc in vitrectomized DME eyes and sustained effectiveness in DME eyes that did not respond to DEX therapy.pt_PT
dc.description.sponsorshipWriting support was provided by Hayward Medical Communications and funded by Alimera Sciences Ltd. This paper was funded by Alimera Sciences Ltd.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCoelho J, Malheiro L, Melo Beirão J, Meireles A, Pessoa B. Real-world retrospective comparison of 0.19 mg fluocinolone acetonide and 0.7 mg dexamethasone intravitreal implants for the treatment of diabetic macular edema in vitrectomized eyes. Clin Ophthalmol. 2019;13:1751‐1759. Published 2019 Sep 9. doi:10.2147/OPTH.S201611pt_PT
dc.identifier.doi10.2147/OPTH.S201611pt_PT
dc.identifier.issn1177-5467
dc.identifier.issn1177-5483
dc.identifier.urihttp://hdl.handle.net/10400.16/2369
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherDove Medical Presspt_PT
dc.relation.publisherversionhttps://www.dovepress.com/real-world-retrospective-comparison-of-019-mg-fluocinolone-acetonide-a-peer-reviewed-article-OPTHpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectdexamethasone implantpt_PT
dc.subjectdiabetic macular edemapt_PT
dc.subjectfluocinolone acetonidept_PT
dc.subjectintravitreal implantspt_PT
dc.subjectreal-worldpt_PT
dc.subjectvitrectomypt_PT
dc.titleReal-world retrospective comparison of 0.19 mg fluocinolone acetonide and 0.7 mg dexamethasone intravitreal implants for the treatment of diabetic macular edema in vitrectomized eyespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceNew Zealandpt_PT
oaire.citation.endPage1759pt_PT
oaire.citation.startPage1751pt_PT
oaire.citation.titleClinical ophthalmology (Auckland, N.Z.)pt_PT
oaire.citation.volume13pt_PT
person.familyNameCoelho
person.familyNameMalheiro
person.familyNameMeireles
person.familyNamePessoa
person.givenNameJoão
person.givenNameLuisa
person.givenNameAngelina
person.givenNameBernardete
person.identifier.ciencia-id0E1B-7EB2-B90F
person.identifier.orcid0000-0003-2261-5682
person.identifier.orcid0000-0001-9937-6806
person.identifier.orcid0000-0001-9148-2786
person.identifier.orcid0000-0002-5673-1561
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication786469ad-6b28-478e-b7b5-5e4cde542164
relation.isAuthorOfPublication8832627a-5103-43bb-a479-6556c8b18d44
relation.isAuthorOfPublicationfa0e3b13-5da3-4f74-a184-22358fc19d38
relation.isAuthorOfPublication.latestForDiscovery9d2244b9-b054-46ab-8d35-d0a369849715

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