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Neutrophil gelatinase-associated lipocalin in kidney transplantation is an early marker of graft dysfunction and is associated with one-year renal function

2013Journal article Open access
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dc.contributor.authorFonseca, Isabel
dc.contributor.authorCarlos Oliveira, José
dc.contributor.authorAlmeida, M.
dc.contributor.authorCruz, M.
dc.contributor.authorMalho, A.
dc.contributor.authorMartins, La Salete
dc.contributor.authorDias, L.
dc.contributor.authorPedroso, S.
dc.contributor.authorSantos, J.
dc.contributor.authorLobato, L.
dc.contributor.authorCastro-Henriques, A.
dc.contributor.authorMendonça, D.
dc.date.accessioned2014-01-06T13:03:21Z
dc.date.available2014-01-06T13:03:21Z
dc.date.issued2013
dc.description.abstractUrinary neutrophil gelatinase-associated lipocalin (uNGAL) has been suggested as potential early marker of delayed graft function (DGF) following kidney transplantation (KTx). We conducted a prospective study in 40 consecutive KTx recipients to evaluate serial changes of uNGAL within the first week after KTx and assess its performance in predicting DGF (dialysis requirement during initial posttransplant week) and graft function throughout first year. Urine samples were collected on post-KTx days 0, 1, 2, 4, and 7. Linear mixed and multivariable regression models, receiver-operating characteristic (ROC), and areas under ROC curves were used. At all-time points, mean uNGAL levels were significantly higher in patients developing DGF (n = 18). Shortly after KTx (3-6 h), uNGAL values were higher in DGF recipients (on average +242 ng/mL, considering mean dialysis time of 4.1 years) and rose further in following days, contrasting with prompt function recipients. Day-1 uNGAL levels accurately predicted DGF (AUC-ROC = 0.93), with a performance higher than serum creatinine (AUC-ROC = 0.76), and similar to cystatin C (AUC-ROC = 0.95). Multivariable analyses revealed that uNGAL levels at days 4 and 7 were strongly associated with one-year serum creatinine. Urinary NGAL is an early marker of graft injury and is independently associated with dialysis requirement within one week after KTx and one-year graft function.por
dc.description.sponsorshipThe authors recognize and thank Abbott Laboratories for their valuable contribution for donating kits used for testing almost 200 samples. The remaining kits were financed by funds of Unit for Multidisciplinary Investigation in Biomedicine, Porto, Portugalpor
dc.identifier.citationJ Transplant. 2013;2013:650123por
dc.identifier.issn2090-0007
dc.identifier.urihttp://hdl.handle.net/10400.16/1549
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherHindawi Publishing Corporationpor
dc.relation.publisherversionhttp://dx.doi.org/10.1155/2013/650123por
dc.titleNeutrophil gelatinase-associated lipocalin in kidney transplantation is an early marker of graft dysfunction and is associated with one-year renal functionpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceUnited States of Americapor
oaire.citation.titleJournal of Transplantationpor
oaire.citation.volume2013por
person.familyNameFonseca
person.familyNameOliveira
person.familyNameMartins
person.givenNameIsabel
person.givenNameJosé Carlos
person.givenNameLa Salete
person.identifier415128
person.identifier806053
person.identifier1911437
person.identifier.ciencia-id6716-A5D1-FB3F
person.identifier.ciencia-id801F-D4FE-8694
person.identifier.ciencia-id7A1B-8631-FC46
person.identifier.orcid0000-0001-8984-1751
person.identifier.orcid0000-0003-2142-6839
person.identifier.orcid0000-0002-6110-2102
person.identifier.ridK-6339-2013
person.identifier.scopus-author-id55941495000
person.identifier.scopus-author-id56207848700
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication2c7a2607-6376-486e-9ad5-490d0032946c
relation.isAuthorOfPublicationbd6d8008-2622-4368-8ded-4ec1c1160c82
relation.isAuthorOfPublication71fef9db-e03d-423a-af46-2909891b037d
relation.isAuthorOfPublication.latestForDiscovery2c7a2607-6376-486e-9ad5-490d0032946c

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