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Human Peripheral Blood Gamma Delta T Cells: Report on a Series of Healthy Caucasian Portuguese Adults and Comprehensive Review of the Literature

2020Journal article Open access
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dc.contributor.authorFonseca, Sónia
dc.contributor.authorPereira, Vanessa
dc.contributor.authorLau, Catarina
dc.contributor.authorTeixeira, Maria dos Anjos
dc.contributor.authorBini-Antunes, Marika
dc.contributor.authorLima, Margarida
dc.date.accessioned2021-11-16T10:33:20Z
dc.date.available2021-11-16T10:33:20Z
dc.date.issued2020
dc.description.abstractGamma delta T cells (Tc) are divided according to the type of Vδ and Vγ chains they express, with two major γδ Tc subsets being recognized in humans: Vδ2Vγ9 and Vδ1. Despite many studies in pathological conditions, only a few have quantified the γδ Tc subsets in healthy adults, and a comprehensive review of the factors influencing its representation in the blood is missing. Here we quantified the total γδ Tc and the Vδ2/Vγ9 and Vδ1 Tc subsets in the blood from 30 healthy, Caucasian, Portuguese adults, we characterized their immunophenotype by 8-color flow cytometry, focusing in a few relevant Tc markers (CD3/TCR-γδ, CD5, CD8), and costimulatory (CD28), cytotoxic (CD16) and adhesion (CD56) molecules, and we examined the impacts of age and gender. Additionally, we reviewed the literature on the influences of race/ethnicity, age, gender, special periods of life, past infections, diet, medications and concomitant diseases on γδ Tc and their subsets. Given the multitude of factors influencing the γδ Tc repertoire and immunophenotype and the high variation observed, caution should be taken in interpreting "abnormal" γδ Tc values and repertoire deviations, and the clinical significance of small populations of "phenotypically abnormal" γδ Tc in the blood.pt_PT
dc.description.sponsorshipThe Centro Hospitalar Universitário do Porto made available the necessary infrastructure and equipment and gave financial support to this study (grant 036/11-021-DEFI/036-CES)pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFonseca S, Pereira V, Lau C, Teixeira MDA, Bini-Antunes M, Lima M. Human Peripheral Blood Gamma Delta T Cells: Report on a Series of Healthy Caucasian Portuguese Adults and Comprehensive Review of the Literature. Cells. 2020;9(3):729. Published 2020 Mar 16. doi:10.3390/cells9030729pt_PT
dc.identifier.doi10.3390/cells9030729pt_PT
dc.identifier.issn2073-4409
dc.identifier.urihttp://hdl.handle.net/10400.16/2543
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2073-4409/9/3/729pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectVdelta1pt_PT
dc.subjectVdelta2pt_PT
dc.subjectgamma delta T cell repertoirept_PT
dc.subjectgamma delta T cellspt_PT
dc.subjecthuman cytomegaloviruspt_PT
dc.subjecthuman herpes virusespt_PT
dc.subjectimmune responsept_PT
dc.subjectnormal reference valuespt_PT
dc.titleHuman Peripheral Blood Gamma Delta T Cells: Report on a Series of Healthy Caucasian Portuguese Adults and Comprehensive Review of the Literaturept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceSwitzerlandpt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage729pt_PT
oaire.citation.titleCellspt_PT
oaire.citation.volume9pt_PT
person.familyNameLima
person.givenNameMargarida
person.identifier.ciencia-id8410-F6C9-183F
person.identifier.orcid0000-0001-9702-5260
person.identifier.ridS-7466-2016
person.identifier.scopus-author-id7202143317
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication1559a9cf-10eb-4d08-b39b-b58079d3bf45
relation.isAuthorOfPublication.latestForDiscovery1559a9cf-10eb-4d08-b39b-b58079d3bf45

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