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SARS-CoV-2 Infection Drives a Glycan Switch of Peripheral T Cells at Diagnosis

2021Journal article Open access
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dc.contributor.authorAlves, Inês
dc.contributor.authorVicente, Manuel Machado
dc.contributor.authorGaifem, Joana
dc.contributor.authorFernandes, Ângela
dc.contributor.authorDias, Ana Mendes
dc.contributor.authorRodrigues, Cláudia Sousa
dc.contributor.authorOliveira, José Carlos
dc.contributor.authorSeixas, Nair
dc.contributor.authorMalheiro, Luis
dc.contributor.authorAbreu, Miguel
dc.contributor.authorSarmento e Castro, Rui
dc.contributor.authorPinho, Salomé Soares
dc.date.accessioned2023-10-17T11:47:51Z
dc.date.available2023-10-17T11:47:51Z
dc.date.issued2021
dc.description.abstractCOVID-19 is a highly selective disease in which SARS-CoV-2 infection can result in different clinical manifestations ranging from asymptomatic/mild to severe disease that requires hospitalization. In this study, we demonstrated that SARS-CoV-2 infection results in a glycosylation reprogramming of circulating lymphocytes at diagnosis. We identified a specific glycosignature of T cells, defined upon SARS-CoV-2 infection and apparently triggered by a serological factor. This specific glycan switch of T cells is detected at diagnosis being more pronounced in asymptomatic patients. We further demonstrated that asymptomatic patients display an increased expression of a viral-sensing receptor through the upregulation of DC-SIGN in monocytes. We showed that higher levels of DC-SIGN in monocytes at diagnosis correlates with better COVID-19 prognosis. This new evidence pave the way to the identification of a novel glycan-based response in T cells that may confer protection against SARS-CoV-2 infection in asymptomatic patients, highlighting a novel prognostic biomarker and potential therapeutic target.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAlves I, Vicente MM, Gaifem J, et al. SARS-CoV-2 Infection Drives a Glycan Switch of Peripheral T Cells at Diagnosis. J Immunol. 2021;207(6):1591-1598. doi:10.4049/jimmunol.2100131pt_PT
dc.identifier.doi10.4049/jimmunol.2100131pt_PT
dc.identifier.issn0022-1767
dc.identifier.issn1550-6606
dc.identifier.urihttp://hdl.handle.net/10400.16/2813
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWilliams & Wilkinspt_PT
dc.relation.publisherversionhttps://journals.aai.org/jimmunol/article/207/6/1591/234181/SARS-CoV-2-Infection-Drives-a-Glycan-Switch-ofpt_PT
dc.titleSARS-CoV-2 Infection Drives a Glycan Switch of Peripheral T Cells at Diagnosispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceUnited States of Americapt_PT
oaire.citation.endPage1598pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage1591pt_PT
oaire.citation.titleThe Journal of Immunologypt_PT
oaire.citation.volume207pt_PT
person.familyNameOliveira
person.familyNameVieira Braga de Araújo Abreu
person.givenNameJosé Carlos
person.givenNameMiguel
person.identifier806053
person.identifier.ciencia-id801F-D4FE-8694
person.identifier.ciencia-id5812-146E-1715
person.identifier.orcid0000-0003-2142-6839
person.identifier.orcid0000-0001-6999-6641
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication0c2a26b0-8a1e-4c20-8e97-09abcce39e3d
relation.isAuthorOfPublication.latestForDiscoverybd6d8008-2622-4368-8ded-4ec1c1160c82

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