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Sleep disturbances in Parkinson's disease are associated with central parkinsonian pain

2019Journal article Open access
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dc.contributor.authorVila-Chã, N.
dc.contributor.authorCavaco, Sara
dc.contributor.authorMendes, A.
dc.contributor.authorGonçalves, A.
dc.contributor.authorMoreira, I.
dc.contributor.authorFernandes, J.
dc.contributor.authorDamásio, Joana
dc.contributor.authorAzevedo, Luís
dc.contributor.authorCastro-Lopes, Jose
dc.date.accessioned2020-05-22T16:34:30Z
dc.date.available2020-05-22T16:34:30Z
dc.date.issued2019
dc.description.abstractIntroduction: Sleep disturbances and pain are common non-motor symptoms in Parkinson's disease (PD). This study aimed to explore the association between these two symptoms in a cohort of patients with PD. Materials and methods: The Parkinson's Disease Sleep Scale (PDSS-2) was used to identify sleep disturbances in a series of 229 PD patients. The identification and characterization of pain was performed by a semi-structured interview and by the application of the Ford classification and the Brief Pain Inventory (BPI). The Unified Parkinson's Disease Rating Scale-III, Hoehn & Yahr (H&Y), and Schwab and England Independence Scale were used to assess motor symptoms and functional independence in off and on conditions. The Hospital Anxiety and Depression Scale (HADS) and SF-36 were applied to screen for anxiety and depression and to evaluate the quality of life. Non-parametric tests were used for group comparisons and logistic regressions were applied to explore predictors of sleep disturbances. Results: Seventy-five (33%) patients had clinically relevant sleep disturbances (PDSS-2≥18) and 162 patients (71%) reported pain. Of those with pain, 38 (24%) had central parkinsonian pain. PD patients with sleep disturbances experienced more pain and had more severe motor symptoms, lower functional independence, more anxiety and depression symptoms, and worst quality of life. Among patients with pain, central parkinsonian pain was the subtype of pain with the highest odds of sleep disturbances, even when taking into account motor symptoms (H&Y off), motor fluctuations, intensity of pain (BPI), and symptoms of anxiety and depression (HADS). Conclusions: The association between pain and sleep disturbances in PD appears to be dependent on subtype of pain. The close relationship between central parkinsonian pain and sleep disturbances in PD raises the possibility of common pathophysiological mechanisms. A better understanding of the relationship between sleep disturbances and central parkinsonian pain may contribute to the development of new care strategies in PD patients.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationVila-Chã N, Cavaco S, Mendes A, et al. Sleep disturbances in Parkinson's disease are associated with central parkinsonian pain. J Pain Res. 2019;12:2137‐2144. Published 2019 Jul 12. doi:10.2147/JPR.S206182pt_PT
dc.identifier.doi10.2147/JPR.S206182pt_PT
dc.identifier.issn1178-7090
dc.identifier.urihttp://hdl.handle.net/10400.16/2399
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherDove Medical Presspt_PT
dc.relation.publisherversionhttps://www.dovepress.com/sleep-disturbances-in-parkinsons-disease-are-associated-with-central-p-peer-reviewed-fulltext-article-JPRpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectParkinson’s diseasept_PT
dc.subjectcentral parkinsonian painpt_PT
dc.subjectsleep disturbancespt_PT
dc.titleSleep disturbances in Parkinson's disease are associated with central parkinsonian painpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceNew Zealandpt_PT
oaire.citation.endPage2144pt_PT
oaire.citation.startPage2137pt_PT
oaire.citation.titleJournal of pain researchpt_PT
oaire.citation.volume12pt_PT
person.familyNameCavaco
person.familyNameDamásio
person.familyNameAzevedo
person.familyNameCastro-Lopes
person.givenNameSara
person.givenNameJoana
person.givenNameLuís
person.givenNameJose
person.identifier224858
person.identifierR-000-8NP
person.identifier.ciencia-idF716-6B7B-8317
person.identifier.ciencia-id8917-86CE-D005
person.identifier.ciencia-id0E14-F84C-94E1
person.identifier.ciencia-id6F1A-743B-9C35
person.identifier.orcid0000-0001-7428-2854
person.identifier.orcid0000-0002-6539-6398
person.identifier.orcid0000-0002-8421-2937
person.identifier.orcid0000-0002-0357-7409
person.identifier.ridJ-7819-2012
person.identifier.ridJ-9346-2013
person.identifier.scopus-author-id6506957934
person.identifier.scopus-author-id55274476300
person.identifier.scopus-author-id6701666967
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication.latestForDiscoveryf0c141c2-641f-4eb4-bf5e-6792c15ffddb

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