Repository logo
 
Publication

Thymic Function as a Predictor of Immune Recovery in Chronically HIV-Infected Patients Initiating Antiretroviral Therapy

2019Journal article Open access
Simple item page
dc.contributor.authorRb-Silva, R.
dc.contributor.authorNobrega, C.
dc.contributor.authorAzevedo, C.
dc.contributor.authorAthayde, E.
dc.contributor.authorCanto-Gomes, J.
dc.contributor.authorFerreira, I.
dc.contributor.authorCheynier, R.
dc.contributor.authorYates, A.
dc.contributor.authorHorta, Ana
dc.contributor.authorCorreia-Neves, M.
dc.date.accessioned2020-05-12T10:04:01Z
dc.date.available2020-05-12T10:04:01Z
dc.date.issued2019
dc.description.abstractPoor immunological responders (PIR) are HIV-infected patients with virologic suppression upon antiretroviral therapy (ART) but persistently low CD4+ T cell counts. Early identification of PIR is important given their higher morbimortality compared to adequate immune responders (AIR). In this study, 33 patients severely lymphopenic at ART onset, were followed for at least 36 months, and classified as PIR or AIR using cluster analysis grounded on their CD4+ T cell count trajectories. Based on a variety of immunological parameters, we built predictive models of PIR/AIR outcome using logistic regression. All PIR had CD4+ T cell counts consistently below 500 cells/μL, while all AIR reached this threshold. AIR showed a higher percentage of recent thymic emigrants among CD4+ T cells; higher numbers of sj-TRECs and greater sj/β TREC ratios; and significant increases in thymic volume from baseline to 12 months of ART. We identified mathematical models that correctly predicted PIR/AIR outcome after 36 months of therapy in 77-87% of the cases, based on observations made until 2-6 months after ART onset. This study highlights the importance of thymic activity in the immune recovery of severely lymphopenic patients, and may help to select the patients that will benefit from closer follow-up or novel therapeutic approaches.pt_PT
dc.description.sponsorshipThis work was supported by: FEDER, through the Competitiveness Factors Operational Program (COMPETE); by National funds, through the Foundation for Science and Technology (FCT), under the scope of the project POCI-01-0145-FEDER-00(7038) and by Programa Gilead GÉNESE (PGG/018/2017). RR-S and JC-G were supported by FCT grants, in the context of PhDOC—Doctoral Program in Aging and Chronic Diseases (PD/BD/106047/2015 and PD/BD/137433/2018, respectively). CN was also supported by a grant from FCT (SFRH/BPD/112001/2015). CA and EA were partially supported by Portuguese Funds through FCT within the project UID/MAT/00013/2013. AY was supported by Arthritis Research UK.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRb-Silva R, Nobrega C, Azevedo C, et al. Thymic Function as a Predictor of Immune Recovery in Chronically HIV-Infected Patients Initiating Antiretroviral Therapy. Front Immunol. 2019;10:25. Published 2019 Feb 5. doi:10.3389/fimmu.2019.00025pt_PT
dc.identifier.doi10.3389/fimmu.2019.00025pt_PT
dc.identifier.issn1664-3224
dc.identifier.urihttp://hdl.handle.net/10400.16/2381
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontiers Mediapt_PT
dc.relation.publisherversionhttps://www.frontiersin.org/articles/10.3389/fimmu.2019.00025/fullpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCD4+ T cellspt_PT
dc.subjectHIV infectionpt_PT
dc.subjectantiretroviral therapypt_PT
dc.subjectimmune activationpt_PT
dc.subjectimmune recoverypt_PT
dc.subjectpoor immunological responderspt_PT
dc.subjectpredictive modelingpt_PT
dc.subjectthymic functionpt_PT
dc.subjectept_PT
dc.titleThymic Function as a Predictor of Immune Recovery in Chronically HIV-Infected Patients Initiating Antiretroviral Therapypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMAT%2F00013%2F2013/PT
oaire.citation.conferencePlaceSwitzerlandpt_PT
oaire.citation.startPage25pt_PT
oaire.citation.titleFrontiers in immunologypt_PT
oaire.citation.volume10pt_PT
oaire.fundingStream5876
person.familyNameHorta
person.givenNameAna
person.identifier.orcid0000-0003-3342-9762
person.identifier.scopus-author-id56374932200
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicatione1e49d09-03b1-48bc-bd90-9cb4fdffbc1a
relation.isAuthorOfPublication.latestForDiscoverye1e49d09-03b1-48bc-bd90-9cb4fdffbc1a
relation.isProjectOfPublication898f0e5a-ddd9-44d4-9dba-caa6d0b0a007
relation.isProjectOfPublication.latestForDiscovery898f0e5a-ddd9-44d4-9dba-caa6d0b0a007

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Thymic Function as a Predictor.pdf
Size:
1.51 MB
Format:
Adobe Portable Document Format
Download

Collections

SINF - Artigos publicados em revistas indexadas na Pubmed/Medline