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Nephrotic Syndrome as a Cause of Transient Clinical Hypothyroidism

2021-08Journal article Open access
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dc.contributor.authorBenido Silva, Vânia
dc.contributor.authorPereira, Maria Teresa
dc.contributor.authorLeal Moreira, Carla
dc.contributor.authorSantos Monteiro, Sílvia
dc.contributor.authorInácio, Isabel
dc.contributor.authorCardoso, Helena
dc.date.accessioned2023-10-24T11:21:18Z
dc.date.available2023-10-24T11:21:18Z
dc.date.issued2021-08
dc.description.abstractNephrotic syndrome may trigger the onset of hypothyroidism, promoting massive urinary protein losses including thyroxine (T4) and triiodothyronine (T3) along with their binding proteins. At an early stage, a clinical and biochemical euthyroid state is expected. However, in patients with prolonged and severe proteinuria, especially with concomitant low thyroid reserve, urinary losses of free and protein-bound thyroid hormones are sufficiently pronounced to induce a subclinical or overt hypothyroidism. Despite its high prevalence in clinical practice, the literature lacks case reports of newly diagnosed clinical hypothyroidism due to NS in adults, making this condition under-recognized. We report a case of a 23-year-old man with previous normal thyroid function who developed overt hypothyroidism due to a severe nephrotic syndrome, requiring supplementation with levothyroxine (LT). After the patient had undergone bilateral nephrectomy, treatment with LT was discontinued and thyroid function normalized.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBenido Silva V, Pereira MT, Moreira CL, Santos Monteiro S, Inácio I, Cardoso MH. Nephrotic Syndrome as a Cause of Transient Clinical Hypothyroidism. Case Rep Endocrinol. 2021;2021:5523929. doi:10.1155/2021/5523929pt_PT
dc.identifier.doi10.1155/2021/5523929pt_PT
dc.identifier.issn2090-651X
dc.identifier.issn2090-6501
dc.identifier.urihttp://hdl.handle.net/10400.16/2847
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherHindawi Pub. Corppt_PT
dc.relation.publisherversionhttps://www.hindawi.com/journals/crie/2021/5523929/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleNephrotic Syndrome as a Cause of Transient Clinical Hypothyroidismpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceUnited States of Americapt_PT
oaire.citation.endPage5pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleCase Reports in Endocrinologypt_PT
oaire.citation.volume2021pt_PT
person.familyNameBenido Silva
person.familyNamePereira
person.familyNameLeal Moreira
person.familyNameSantos Monteiro
person.familyNameCardoso
person.givenNameVânia
person.givenNameMaria Teresa
person.givenNameCarla
person.givenNameSílvia
person.givenNameMaria Helena
person.identifier.ciencia-id0212-CE45-8889
person.identifier.orcid0000-0002-8206-7414
person.identifier.orcid0000-0001-8073-9734
person.identifier.orcid0000-0002-7913-4460
person.identifier.orcid0000-0003-2198-6668
person.identifier.orcid0000-0002-9465-5918
person.identifier.ridP-6822-2017
person.identifier.scopus-author-id56817857700
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationcbbb5c72-022e-4e03-a15c-0308feab5acb
relation.isAuthorOfPublication344d788b-4117-41c8-a131-e37691d312ec
relation.isAuthorOfPublication601153a6-9e9a-43e1-a395-3e00cbe30a19
relation.isAuthorOfPublication8f405657-741d-4c68-a871-727d6fc2f906
relation.isAuthorOfPublicationa1dc4387-f35c-447a-be66-d81fc5fde281
relation.isAuthorOfPublication.latestForDiscovery601153a6-9e9a-43e1-a395-3e00cbe30a19

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