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The epidemiology of multiple sclerosis in the entre Douro e Vouga region of northern Portugal: a multisource population-based study

2020-05-19Journal article Open access
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dc.contributor.authorBranco, Mariana
dc.contributor.authorAlves, Ivânia
dc.contributor.authorMartins da Silva, Ana
dc.contributor.authorPinheiro, Joaquim
dc.contributor.authorSá, Maria José
dc.contributor.authorCorreia, Inês
dc.contributor.authorSousa, Lívia
dc.contributor.authorBrandão, Eva
dc.contributor.authorVeira, Carlos
dc.contributor.authorGomes, Bernardo
dc.contributor.authorRuano, Luis
dc.date.accessioned2021-11-09T15:17:06Z
dc.date.available2021-11-09T15:17:06Z
dc.date.issued2020-05-19
dc.description.abstractBackground: The prevalence of Multiple Sclerosis (MS) has been increasing worldwide and the north-south gradient of prevalence may be disappearing in the Northern hemisphere. The few previous prevalence studies performed in Portugal have reported a lower prevalence than the average for Western Europe. The aim of this study is to estimate the prevalence of MS in the Entre Douro e Vouga region, in Northern Portugal. Methods: Multiple overlapping sources were used to ascertain all cases from the reference population: records from hospitals in the region and neighbouring regions; diagnostic databases of primary care physicians; and applications for disability benefits. The prevalence date was set at 1 January 2014. The reference population was 274,859 inhabitants. Patients' neurologists were contacted to retrieve clinical information and confirm the diagnosis based. Results: A total of 177 patients were identified after eliminating duplicates from different sources. The female to male ratio was 1.9 and the mean age at disease onset was 33.5 (standard deviation: 10.3). Clinically isolated syndrome accounted for 9.0% of patients, relapsing remitting for 58.8%, secondary progressive for 20.3% and primary progressive for 11.8%. The prevalence was estimated in 64.4 patients per 100,000 (95% confidence interval: 54.9;73.9). Conclusions: In this study we report a higher point prevalence of MS than had been previously described in Portugal, but still far from the higher values recently reported in other Southern European countries.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBranco M, Alves I, Martins da Silva A, et al. The epidemiology of multiple sclerosis in the entre Douro e Vouga region of northern Portugal: a multisource population-based study. BMC Neurol. 2020;20(1):195. Published 2020 May 19. doi:10.1186/s12883-020-01755-8pt_PT
dc.identifier.doi10.1186/s12883-020-01755-8pt_PT
dc.identifier.issn1471-2377
dc.identifier.urihttp://hdl.handle.net/10400.16/2531
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBioMed Centralpt_PT
dc.relation.publisherversionhttps://bmcneurol.biomedcentral.com/articles/10.1186/s12883-020-01755-8pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectEpidemiologypt_PT
dc.subjectMultiple sclerosispt_PT
dc.subjectPortugalpt_PT
dc.subjectPrevalencept_PT
dc.titleThe epidemiology of multiple sclerosis in the entre Douro e Vouga region of northern Portugal: a multisource population-based studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceEnglandpt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage195pt_PT
oaire.citation.titleBMC Neurologypt_PT
oaire.citation.volume20pt_PT
person.familyNameMartins da Silva
person.givenNameAna
person.identifier.ciencia-id1116-6606-5CF5
person.identifier.orcid0000-0002-1409-0831
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicatione2fd5aa2-f733-43eb-b339-14fcaa3d881d
relation.isAuthorOfPublication.latestForDiscoverye2fd5aa2-f733-43eb-b339-14fcaa3d881d

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