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Innovative approach to a functional mediastinal paraganglioma with anomalous coronary supply: a case report

2020-04-17Journal article Open access
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dc.contributor.authorLuz, André
dc.contributor.authorAmaral, Cláudia
dc.contributor.authorSilveira, Inês
dc.contributor.authorTrêpa, Maria
dc.date.accessioned2021-11-22T14:19:30Z
dc.date.available2021-11-22T14:19:30Z
dc.date.issued2020-04-17
dc.description.abstractBackground: Mediastinal paragangliomas (PGs) are rare and particularly challenging neuroendocrine tumours. Clinical presentation is heterogeneous and tumour resection can be challenging due to bleeding and the risk of catecholamine surges in functional tumours. Case summary: A 36-year-old man with multiple cardiovascular risk factors was admitted with subacute heart failure. Investigations revealed a large non-metastatic functional mediastinal PG irrigated mainly by a left circumflex coronary anomalous feeder branch. The surgical risk was deemed very high due to patient comorbidities, tumour vascularization, and close relation to major thoracic structures. A multidisciplinary team decided to perform embolization of the anomalous coronary branch followed by peptide-receptor radionuclide therapy with 177-LuDOTATE aiming to decrease tumour size and perioperative risk. Follow-up studies showed a reduction in tumour vascularization, size, and hormonal production. Discussion: The innovative strategy of combining embolization of the anomalous feeder branch with radionuclide therapy proved to be a promising approach.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationTrêpa M, Silveira I, Amaral C, Luz A. Innovative approach to a functional mediastinal paraganglioma with anomalous coronary supply: a case report. Eur Heart J Case Rep. 2020;4(3):1-6. doi:10.1093/ehjcr/ytaa062pt_PT
dc.identifier.doi10.1093/ehjcr/ytaa062pt_PT
dc.identifier.issn2514-2119
dc.identifier.urihttp://hdl.handle.net/10400.16/2595
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherOxford University Presspt_PT
dc.relation.publisherversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319854/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectCase reportpt_PT
dc.subjectCoronary embolizationpt_PT
dc.subjectMediastinal paragangliomapt_PT
dc.subjectNeuroendocrine tumourpt_PT
dc.subjectRadionuclide therapypt_PT
dc.titleInnovative approach to a functional mediastinal paraganglioma with anomalous coronary supply: a case reportpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceEnglandpt_PT
oaire.citation.endPage6pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleEuropean Heart Journal - Case Reportspt_PT
oaire.citation.volume4pt_PT
person.familyNameLuz
person.familyNameSilveira
person.familyNameTrêpa
person.givenNameAndré
person.givenNameInês
person.givenNameMaria
person.identifier.ciencia-id5110-718E-D5BA
person.identifier.ciencia-idC31B-B4A0-9BFD
person.identifier.orcid0000-0002-2339-7341
person.identifier.orcid0000-0002-3120-4175
person.identifier.orcid0000-0002-7624-7750
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication06585520-b729-428f-b140-c800372c9f87
relation.isAuthorOfPublication92f00469-6492-45dd-b353-827bf94a9fb6
relation.isAuthorOfPublication3f0f0b34-eed3-4777-98d9-37221c05b4ef
relation.isAuthorOfPublication.latestForDiscovery92f00469-6492-45dd-b353-827bf94a9fb6

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