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Intradermal Tests With Drugs: An Approach to Standardization

2020-05-15Journal article Open access
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dc.contributor.authorBarbaud, Annick
dc.contributor.authorWeinborn, Marie
dc.contributor.authorGarvey, Lene Heise
dc.contributor.authorTesti, Sergio
dc.contributor.authorKvedariene, Violeta
dc.contributor.authorBavbek, Sevim
dc.contributor.authorMosbech, Holger
dc.contributor.authorgomes, eva
dc.contributor.authorAberer, Werner
dc.contributor.authorElberink, Hanneke N. G. Oude
dc.contributor.authorTorres, Maria Jose
dc.contributor.authorPonvert, Claude
dc.contributor.authorAyav, C.
dc.contributor.authorGooi, Jimmy
dc.contributor.authorBrockow, Knut
dc.date.accessioned2021-11-23T15:12:42Z
dc.date.available2021-11-23T15:12:42Z
dc.date.issued2020-05-15
dc.description.abstractBackground: Intradermal tests (IDTs) are performed and interpreted differently in drug allergy centers making valid comparison of results difficult. Objective: To reduce method-related and intercenter variability of IDTs by the introduction of a standardized method. Materials and methods: In 11 centers of the European Network for Drug Allergy, IDTs were prospectively performed with saline and with amoxicillin (20 mg/ml) using (1) the local method and (2) the standardized European Network in Drug Allergy (ENDA) method (0.02 ml). The diameters of the initial injection wheal (Wi) for the different volumes and sites injected obtained from each center were analyzed. Results: The most reproducible method was to fill a syringe with test solution, then expel the excess fluid to obtain exactly 0.02 ml. The median Wi diameter with 0.02 ml injection using the standardized method was 5 mm [range 2-10 mm; interquartile range (IQR) 5-5 mm; n = 1,096] for saline and 5 mm (range 2-9 mm; IQR = 4.5-5 mm; n = 240) for amoxicillin. IDT injection sites did not affect the Wi diameter. Training improved precision and reduced the variability of Wi diameters. Conclusion: Using the standardized IDT method described in this multicenter study helped to reduce variability, enabling more reliable comparison of results between individuals and centers.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBarbaud A, Weinborn M, Garvey LH, et al. Intradermal Tests With Drugs: An Approach to Standardization. Front Med (Lausanne). 2020;7:156. doi:10.3389/fmed.2020.00156pt_PT
dc.identifier.doi10.3389/fmed.2020.00156pt_PT
dc.identifier.issn2296-858X
dc.identifier.urihttp://hdl.handle.net/10400.16/2628
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontiers Mediapt_PT
dc.relation.publisherversionhttps://www.frontiersin.org/articles/10.3389/fmed.2020.00156/fullpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectamoxicillinpt_PT
dc.subjectdrug allergypt_PT
dc.subjectintradermal testpt_PT
dc.subjectspecificity of drug skin testspt_PT
dc.subjectstandardizationpt_PT
dc.titleIntradermal Tests With Drugs: An Approach to Standardizationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceSwitzerlandpt_PT
oaire.citation.startPage156pt_PT
oaire.citation.titleFrontiers in Medicinept_PT
oaire.citation.volume7pt_PT
person.familyNamegomes
person.givenNameeva
person.identifier.ciencia-id0D1C-83A7-A086
person.identifier.orcid0000-0001-8956-9145
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication7e99b85c-5096-43a3-800b-02207a45237d
relation.isAuthorOfPublication.latestForDiscovery7e99b85c-5096-43a3-800b-02207a45237d

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