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Association of the Calcification Score of the Abdominal Aorta, Common Iliac, and Renal Arteries with Outcomes in Living Kidney Donors

2023-05Journal article Open access
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dc.contributor.authorRibeiro, Luís Costa
dc.contributor.authorAlmeida, Manuela
dc.contributor.authorJ, Malheiro
dc.contributor.authorSilva, Filipa
dc.contributor.authorNunes-Carneiro, Diogo
dc.contributor.authorMartins, La Salete
dc.contributor.authorPedroso, Sofia
dc.contributor.authorSilva-Ramos, Miguel
dc.date.accessioned2024-07-04T11:26:06Z
dc.date.available2024-07-04T11:26:06Z
dc.date.issued2023-05
dc.description.abstractBackground: Vascular calcification is an ever-more-common finding in protocoled pre-transplant imaging in living kidney donors. We intended to explore whether a connection could be found between the Agatston calcification score, prior to kidney donation, and post-donation renal function. Methods: This is a retrospective analysis of 156 living kidney donors who underwent living donor nephrectomy between January 2010 and December 2016. We quantified the total calcification score (TCaScore) by calculating the Agatston score for each vessel, abdominal aorta, common iliac, and renal arteries. Donors were placed into two different groups based on their TCaScore: <100 TCaScore group and ≥100 TCaScore group. The relationship between TCaScore, 1-year eGFR, proteinuria, and risk of 1 measurement of decreased renal function (eGFR < 60 mL/min/1.73 m2) over 5 years of follow-up was investigated. Results: The ≥100 TCaScore group consisted of 29 (19%) donors, with a median (interquartile range) calcification score of 164 (117-358). This group was significantly older, 56.7 ± 6.9 vs. 45.5 ± 10.6 (p < 0.001), had a higher average BMI (p < 0.019), and had a lower preoperative eGFR (p < 0.014). The 1-year eGFR was similarly diminished, 69.9 ± 15.7 vs. 76.3 ± 15.5 (p < 0.048), while also having an increased risk of decreased renal function during the follow-up, 22% vs. 48% (p < 0.007). Conclusions: Our study, through univariate analyses, found a relationship between a TCaScore > 100, lower 1-year eGFR, and decreased renal function in 5 years. However, a higher-than-expected vascular calcification should not be an excluding factor in donors, although they may require closer monitoring during follow-up.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRibeiro LC, Almeida M, Malheiro J, et al. Association of the Calcification Score of the Abdominal Aorta, Common Iliac, and Renal Arteries with Outcomes in Living Kidney Donors. J Clin Med. 2023;12(9):3339. doi:10.3390/jcm12093339pt_PT
dc.identifier.doi10.3390/jcm12093339pt_PT
dc.identifier.issn2077-0383
dc.identifier.urihttp://hdl.handle.net/10400.16/2997
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://doi.org/10.3390/jcm12093339pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAgatston scorept_PT
dc.subjectdonor outcomespt_PT
dc.subjectexpanded criteria donorspt_PT
dc.subjectkidney transplantationpt_PT
dc.subjectvascular calcificationpt_PT
dc.titleAssociation of the Calcification Score of the Abdominal Aorta, Common Iliac, and Renal Arteries with Outcomes in Living Kidney Donorspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceSwitzerlandpt_PT
oaire.citation.issue9pt_PT
oaire.citation.startPage3339pt_PT
oaire.citation.titleJournal of Clinical Medicinept_PT
oaire.citation.volume12pt_PT
person.familyNamealmeida
person.familyNameMalheiro
person.familyNameNunes-Carneiro
person.familyNameMartins
person.familyNamePedroso
person.familyNameSilva-Ramos
person.givenNamemanuela
person.givenNameJorge
person.givenNameDiogo
person.givenNameLa Salete
person.givenNameSofia
person.givenNameMiguel
person.identifier1861404
person.identifier1911437
person.identifier.ciencia-id2811-3372-9A87
person.identifier.ciencia-id7A1B-8631-FC46
person.identifier.ciencia-id5A13-E9F2-E5C7
person.identifier.ciencia-idA71F-0CBC-D7F7
person.identifier.orcid0000-0002-0312-3685
person.identifier.orcid0000-0002-9625-5889
person.identifier.orcid0000-0001-5910-2018
person.identifier.orcid0000-0002-6110-2102
person.identifier.orcid0000-0002-8539-906X
person.identifier.orcid0000-0002-1232-3232
person.identifier.ridK-6320-2013
person.identifier.ridN-4077-2013
person.identifier.scopus-author-id26434404600
person.identifier.scopus-author-id56207848700
person.identifier.scopus-author-id22952009900
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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