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Freeze-Dried Softisan® 649-Based Lipid Nanoparticles for Enhanced Skin Delivery of Cyclosporine A

2020Journal article Open access
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dc.contributor.authorSilva, Maria Inês
dc.contributor.authorBarbosa, Ana Isabel
dc.contributor.authorCosta Lima, Sofia A.
dc.contributor.authorCosta, Paulo
dc.contributor.authorT, Torres
dc.contributor.authorReis, Salette
dc.date.accessioned2022-06-30T09:54:03Z
dc.date.available2022-06-30T09:54:03Z
dc.date.issued2020
dc.description.abstractInflammatory skin diseases, including psoriasis and atopic dermatitis, affect around one quarter to one third of the world population. Systemic cyclosporine A, an immunosuppressant agent, is included in the current therapeutic armamentarium of these diseases. Despite being highly effective, it is associated with several side effects, and its topical administration is limited by its high molecular weight and poor water solubility. To overcome these limitations, cyclosporine A was incorporated into solid lipid nanoparticles obtained from Softisan® 649, a commonly used cosmetic ingredient, aiming to develop a vehicle for application to the skin. The nanoparticles presented sizes of around 200 nm, low polydispersity, negative surface charge, and stability when stored for 8 weeks at room temperature or 4 °C. An effective incorporation of 88% of cyclosporine A within the nanoparticles was observed, without affecting its morphology. After the freeze-drying process, the Softisan® 649-based nanoparticles formed an oleogel. Skin permeation studies using pig ear as a model revealed low permeation of the applied cyclosporine A in the freeze-dried form of the nanoparticles in relation to free drug and the freshly prepared nanoparticles. About 1.0 mg of cyclosporine A was delivered to the skin with reduced transdermal permeation. These results confirm local delivery of cyclosporine A, indicating its promising topical administration.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSilva MI, Barbosa AI, Costa Lima SA, Costa P, Torres T, Reis S. Freeze-Dried Softisan® 649-Based Lipid Nanoparticles for Enhanced Skin Delivery of Cyclosporine A. Nanomaterials (Basel). 2020;10(5):986. doi:10.3390/nano10050986pt_PT
dc.identifier.doi10.3390/nano10050986pt_PT
dc.identifier.issn2079-4991
dc.identifier.urihttp://hdl.handle.net/10400.16/2683
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation3Ds - TransDermal Drug Delivery
dc.relationMarine-based nanotechnological approaches for dermatitis in developing countries
dc.relationNot Available
dc.relation.publisherversionhttps://www.mdpi.com/2079-4991/10/5/986pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectFranz-cell permeationpt_PT
dc.subjectcellular uptakept_PT
dc.subjectkeratinocytespt_PT
dc.subjectpig ear skinpt_PT
dc.subjectpseudoplastic propertiespt_PT
dc.subjectsolid lipid nanoparticlespt_PT
dc.titleFreeze-Dried Softisan® 649-Based Lipid Nanoparticles for Enhanced Skin Delivery of Cyclosporine Apt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitle3Ds - TransDermal Drug Delivery
oaire.awardTitleMarine-based nanotechnological approaches for dermatitis in developing countries
oaire.awardTitleNot Available
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FQUI-COL%2F30834%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F147038%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2017/CEECIND%2F01620%2F2017%2FCP1427%2FCT0002/PT
oaire.citation.conferencePlaceSwitzerlandpt_PT
oaire.citation.endPage986pt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPage986pt_PT
oaire.citation.titleNanomaterialspt_PT
oaire.citation.volume10pt_PT
oaire.fundingStream9471 - RIDTI
oaire.fundingStreamPOR_NORTE
oaire.fundingStreamCEEC IND 2017
person.familyNameTorres
person.givenNameTiago
person.identifier1077508
person.identifier.ciencia-idFF1B-8834-7AE0
person.identifier.orcid0000-0003-0404-0870
person.identifier.ridC-2604-2014
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication.latestForDiscovery99c82895-36fa-49af-927a-f75fa1f9bd56
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