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Visceral Obesity and Metabolic Syndrome Are Associated with Well-Differentiated Gastroenteropancreatic Neuroendocrine Tumors

2018-08-27Journal article Open access
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dc.contributor.authorSantos, A.
dc.contributor.authorSantos, A.
dc.contributor.authorCastro, C.
dc.contributor.authorRaposo, L.
dc.contributor.authorPereira, S.
dc.contributor.authorTorres, I.
dc.contributor.authorHenrique, R.
dc.contributor.authorCardoso, H.
dc.contributor.authorMonteiro, M.
dc.date.accessioned2019-07-18T14:28:37Z
dc.date.available2019-07-18T14:28:37Z
dc.date.issued2018-08-27
dc.description.abstractThe determinants for gastroenteropancreatic neuroendocrine tumors (GEP-NET) recent burden are matters of debate. Obesity and metabolic syndrome (MetS) are well established risks for several cancers even though no link with GEP-NETs was yet established. Our aim in this study was to investigate whether well-differentiated GEP-NETs were associated with obesity and MetS. Patients with well-differentiated GEP-NETs (n = 96) were cross-matched for age, gender, and district of residence with a control group (n = 96) derived from the general population in a case-control study. Patients presented gastro-intestinal (75.0%) or pancreatic (22.9%) tumors, grade G1 (66.7%) or G2 (27.1%) with localized disease (31.3%), regional metastasis (16.7%) or distant metastasis (43.8%) at diagnosis, and 45.8% had clinical hormonal syndromes. MetS was defined according to Joint Interim Statement (JIS) criteria. Well-differentiated GEP-NETs were associated with MetS criteria as well as the individual components' waist circumference, fasting triglycerides, and fasting plasma glucose (p = 0.003, p = 0.002, p = 0.011 and p < 0.001, respectively). The likelihood of the association was higher when the number of individual MetS components was greater than four. MetS and some individual MetS components including visceral obesity, dyslipidemia, and increased fasting glucose are associated with well-differentiated GEP-NET. This data provides a novel insight in unraveling the mechanisms leading to GEP-NET disease.pt_PT
dc.description.sponsorshipThis project was funded by a grant from Research Center of IPO-Porto (CI-IPOP 32-2015)pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCancers (Basel). 2018 Aug 27;10(9)pt_PT
dc.identifier.doi10.3390/cancers10090293pt_PT
dc.identifier.issn2072-6694
dc.identifier.urihttp://hdl.handle.net/10400.16/2274
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2072-6694/10/9/293pt_PT
dc.subjectabdominal obesitypt_PT
dc.subjectgastroenteropancreatic neuroendocrine tumorpt_PT
dc.subjectglucose abnormalitiespt_PT
dc.subjectmetabolic syndromept_PT
dc.titleVisceral Obesity and Metabolic Syndrome Are Associated with Well-Differentiated Gastroenteropancreatic Neuroendocrine Tumorspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceSwitzerlandpt_PT
oaire.citation.issue9pt_PT
oaire.citation.startPage293pt_PT
oaire.citation.titleCancerspt_PT
oaire.citation.volume10pt_PT
person.familyNameCardoso
person.givenNameMaria Helena
person.identifier.ciencia-id0212-CE45-8889
person.identifier.orcid0000-0002-9465-5918
person.identifier.ridP-6822-2017
person.identifier.scopus-author-id56817857700
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationa1dc4387-f35c-447a-be66-d81fc5fde281
relation.isAuthorOfPublication.latestForDiscoverya1dc4387-f35c-447a-be66-d81fc5fde281

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